I've been battling CIC and IBS-C for about 12 years. Linzess was the first medication to help me. I started taking it about a year ago and it was life changing. I went from actually never having a BM (only going with enemas) to having a BM once per day. I've never felt better. About 2.5 weeks ago linzess suddenly stopped working. I haven't had a single BM. I don't understand what caused the changed. I'm already on the 290 dose so increasing the dose isn't an option. I appreciate any insight anyone has. Thank you!