Pronunciation: trin-GOLE-zah
Generic name: olezarsen
Dosage form: single-dose autoinjector (80 mg/0.8 mL)
Drug class: Miscellaneous antihyperlipidemic agents

Medically reviewed by Carmen Pope, BPharm. Last updated on Apr 17, 2025.

What is Tryngolza?

Tryngolza is used to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS), alongside dietary changes. It is self-administered via a single-dose auto-injector subcutaneously (under the skin) once a month.

• Dietary changes include reducing fat intake to no more than 0.7 ounces (20 grams) per day.

Tryngolza gained FDA approval on December 19, 2024, and was the first treatment approved for FCS and AP. Clinical trials show it significantly reduces triglycerides.

Tryngolza is made by Ionis Pharmaceuticals Inc.

How does Tryngolza work?

Tryngolza’s mechanism of action involves reducing levels of a specific protein in the blood called apoC-III. This is a key protein produced by the liver for breaking down triglycerides. Tryngolza targets and breaks down the genetic instructions (mRNA) that tell the body to make apoC-III. When there's less apoC-III protein in the blood, the body becomes better at removing fats (specifically triglycerides and VLDL) from the bloodstream.

Tryngolza belongs to the drug class called ASO-GalNAc3 conjugates.

Tryngolza side effects

The most common side effects of Tryngolza are:

• redness or pain at the injection site
• decreased platelets (these are blood cells that help blood clot
•  joint pain or stiffness.

It is not known if Tryngolza is safe and effective in children.

Serious side effects and warnings

Tryngolza may cause an allergic reaction that could be serious. Allergic reactions can include redness of the skin, red itchy bumps (hives), swelling of the face, chills or trouble breathing. Stop taking Tryngolza and call your healthcare provider or get emergency help right away if you have any of these symptoms.

These are not all the possible side effects of Tryngolza. Tell your healthcare provider if you have any side effect that bothers you or that does not go away while taking Tryngolza. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Related/similar drugs

Before taking

Do not use Tryngolza if you have had a serious allergic reaction to olezarsen, Tryngolza, or any of the inactive ingredients in Tryngolza (see ingredient list below).

Before using Tryngolza, tell your healthcare provider about all of your medical conditions, including if you:

• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed.

Pregnancy

It is not known if Tryngolza can harm your unborn baby. Tell your healthcare provider if you become pregnant while using Tryngolza.

Breastfeeding

It is not known if Tryngolza passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby while using Tryngolza.

How do I use Tryngolza?

Read the detailed Instructions for Use that come with the Tryngolza Package Insert for your single-dose autoinjector.

Your healthcare provider will show you and/or your caregiver how to inject Tryngolza the first time.

• Tryngolza is injected under your skin (subcutaneous use) in your stomach area (abdomen) or the front of your upper legs (thighs). Only a healthcare provider or caregiver may give you an injection in the back of your upper arm.
• Tryngolza should be injected 1 time each month.

Stay on your low-fat diet (less than 20 grams of fat each day) while using Tryngolza.

Dietary restrictions with Tryngolza

Tryngolza must be taken with an extremely low-fat diet (20 grams of fat daily limit). This requires careful planning and patients should work with their healthcare provider or a registered dietitian to ensure they're meeting their nutritional needs while staying within these restrictions while receiving Tryngolza.

To visualize 20 grams of fat, here are some common foods and their fat content:

• 1 tablespoon of olive oil = 14 grams of fat
• 1 medium avocado = 21 grams of fat (already exceeds daily limit)
• 1 handful (1 oz) of almonds = 14 grams of fat
• 1 tablespoon of butter = 12 grams of fat
• 2 large eggs = 10 grams of fat
• 3 oz of skinless chicken breast = 3 grams of fat
• 1 slice of cheese = 6 grams of fat

To stay within the 20-gram limit while receiving Tryngolza, patients might eat:

• A small amount of cooking oil (1-2 teaspoons = 5-10g)
• A skinless chicken breast (3g)
• A single egg (5g)
• Plus a few grams from other foods throughout the day.

Tryngolza dosage

The recommended dosage of Tryngolza for FCS is 80 mg administered subcutaneously (under the skin) once monthly.

See the Tryngolza Prescribing Information for more detailed dosing instructions.

What happens if I miss a dose?

If you miss a dose of Tryngolza, take the missed dose as soon as possible. Then inject Tryngolza 1 month from the date of your last dose to get back on a monthly dosing schedule. If you have questions about your dosing schedule, ask your healthcare provider.

What other medicines can affect Tryngolza?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I store Tryngolza?

Store the Tryngolza autoinjector in the refrigerator between 36°F to 46°F (2°C to 8°C) in the original carton.

• Tryngolza can also be stored at room temperature between 59°F to 86°F (15°C to 30°C) in the original carton for up to 6 weeks.
• Do not let Tryngolza reach temperatures above 86°F (30°C).
• Throw away the Tryngolza autoinjector if kept at room temperature longer than 6 weeks.
• Do not freeze.
• Do not expose Tryngolza autoinjector to heat.
• Protect from light.

Keep the Tryngolza autoinjector in the carton until ready to use.

• Do not store the autoinjector with the clear cap removed.

Keep Tryngolza and all medicines out of the reach of children.

Tryngolza ingredients

Active ingredient: olezarsen sodium.

Inactive ingredients: disodium hydrogen phosphate, sodium chloride, sodium dihydrogen phosphate to maintain pH and provide tonicity and water for injection. The solution may include hydrochloric acid and/or sodium hydroxide for pH adjustment.

Available as a Tryngolza single dose autoinjector 80 mg/0.8 mL

Who makes Tryngolza?

Tryngolza is made by Ionis Pharmaceuticals Inc. with headquarters in Carlsbad, California.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer