Zoryve Side Effects

Generic name: roflumilast topical

Medically reviewed by Drugs.com. Last updated on Feb 20, 2025.

Note: This document provides detailed information about Zoryve Side Effects associated with roflumilast topical. Some dosage forms listed on this page may not apply specifically to the brand name Zoryve.

Applies to roflumilast topical: topical application cream.

Serious side effects of Zoryve

Along with its needed effects, roflumilast topical (the active ingredient contained in Zoryve) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking roflumilast topical:

Less common side effects

• bladder pain
• bloody or cloudy urine
• difficult, burning, or painful urination
• frequent urge to urinate
• lower back or side pain

Other side effects of Zoryve

Some side effects of roflumilast topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• body aches or pain
• chills
• cough
• diarrhea
• difficulty in breathing
• ear congestion
• fever
• headache
• loss of voice
• nausea
• pain in the area where the medicine is applied
• sneezing
• sore throat
• stuffy or runny nose
• trouble sleeping
• unusual tiredness or weakness

For healthcare professionals

Applies to roflumilast topical: topical cream, topical foam.

General adverse events

The most common side effect that led to discontinuation was application site urticaria.^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, nausea^[Ref]

Local

• Common (1% to 10%): Application site pain^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia^[Ref]

Respiratory

• Common (1% to 10%): Upper respiratory tract infection^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Further information

Zoryve side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer