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Z-Tuss AC Side Effects

Generic name: chlorpheniramine / codeine

Medically reviewed by Drugs.com. Last updated on Apr 8, 2024.

Note: This document provides detailed information about Z-Tuss AC Side Effects associated with chlorpheniramine / codeine. Some dosage forms listed on this page may not apply specifically to the brand name Z-Tuss AC.

Applies to chlorpheniramine / codeine: oral tablet extended release.

Important warnings This medicine can cause some serious health issues

MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Do not give this medicine to anyone younger than 12 years old, or anyone under 18 who recently had surgery to remove the tonsils or adenoids.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using this medicine and call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are debilitated.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to chlorpheniramine/codeine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release.

General

The most common adverse events were sedation (somnolence, mental clouding, lethargy), impaired mental and physical performance, lightheadedness, dizziness, headache, dry mouth, nausea, vomiting, constipation, shortness of breath, and sweating.[Ref]

Nervous system

Serotonin syndrome has been reported with concomitant opioids and serotonergic drugs.[Ref]

Gastrointestinal

Respiratory

Endocrine

Adrenal insufficiency has been reported with opioid use, most often following greater than one month of use. Androgen deficiency has been reported with chronic opioid use.[Ref]

Dermatologic

Hypersensitivity

Ocular

Cardiovascular

Other

Metabolic

Psychiatric

Hematologic

Musculoskeletal

Genitourinary

References

1. (2010) "Product Information. Zodryl AC Adult (chlorpheniramine-codeine)." codaDOSE Incorporated

2. (2016) "Product Information. Tuzistra XR (chlorpheniramine-codeine)." Vernalis Pharmaceuticals Inc

Further information

Z-Tuss AC side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.