Vicks Sinex 12-Hour Decongestant Nasal Spray Side Effects
Generic name: oxymetazoline nasal
Medically reviewed by Drugs.com. Last updated on Mar 5, 2025.
Note: This document provides detailed information about Vicks Sinex 12-Hour Decongestant Nasal Spray Side Effects associated with oxymetazoline nasal. Some dosage forms listed on this page may not apply specifically to the brand name Vicks Sinex 12-Hour Decongestant Nasal Spray.
Applies to oxymetazoline nasal: nasal spray.
Serious side effects
Along with its needed effects, oxymetazoline nasal (the active ingredient contained in Vicks Sinex 12-Hour Decongestant Nasal Spray) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline nasal:
- Blurred vision
- fast, irregular, or pounding heartbeat
- headache, dizziness, drowsiness, or lightheadedness
- high blood pressure
- increase in runny or stuffy nose
- nervousness
- trembling
- trouble in sleeping
- weakness
Other side effects
Some side effects of oxymetazoline nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Burning, dryness, or stinging inside of nose
- sneezing
For healthcare professionals
Applies to oxymetazoline nasal: nasal solution, nasal spray.
General adverse events
The most commonly reported side effects were discomfort or irritation in the nose, mouth or throat, and sneezing.[Ref]
Gastrointestinal
Cardiovascular
- Very rare (less than 0.01%): Tachycardia, palpitations, increased blood pressure[Ref]
Nervous system
- Very rare (less than 0.01%): Insomnia, nervousness, tremor, anxiety, restlessness, irritability, headache[Ref]
Ocular
- Rare (less than 0.1%): Eye irritation, dryness, discomfort/redness[Ref]
Respiratory
- Rare (less than 0.1%): Discomfort or irritation in the nose, mouth or throat, sneezing
- Frequency not reported: Rhinitis medicamentosa (after prolonged or heavy use)[Ref]
References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. Cerner Multum, Inc. "Australian Product Information."
3. (2001) "Product Information. Afrin (oxymetazoline nasal)." Schering-Plough
Frequently asked questions
More about Vicks Sinex 12-Hour Decongestant Nasal Spray (oxymetazoline nasal)
- Check interactions
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- Reviews (9)
- Dosage information
- During pregnancy
- Drug class: nasal antihistamines and decongestants
- Breastfeeding
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Further information
Vicks Sinex 12-Hour Decongestant Nasal Spray side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.