Tiotropium Side Effects

Medically reviewed by Drugs.com. Last updated on May 22, 2024.

Applies to tiotropium: inhalation capsule, inhalation spray.

Serious side effects of tiotropium

Along with its needed effects, tiotropium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tiotropium:

Other side effects of tiotropium

Some side effects of tiotropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to tiotropium: inhalation aerosol, inhalation capsule.

General

The most commonly reported adverse reaction was dry mouth, usually mild and often resolved during continued treatment.

Other reactions consistent with possible anticholinergic effects included constipation, tachycardia, blurred vision, glaucoma (new onset or worsening), dysuria, and urinary retention.^[Ref]

Respiratory

• Very common (10% or more): Pharyngitis (11.5%)
• Common (1% to 10%): Respiratory tract infection, cough, sinusitis, rhinitis, epistaxis, dysphonia, chest pain, laryngitis
• Rare (less than 0.1%): Epistaxis, bronchospasm,
• Postmarketing reports: Pharyngolaryngeal pain, throat irritation, hoarseness^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations, angina pectoris (including aggravated angina pectoris)
• Uncommon (0.1% to 1%): Atrial fibrillation
• Rare (less than 0.1%): Palpitations, supraventricular tachycardia, tachycardia^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Rare (less than 0.1%): Angioneurotic edema, urticaria, skin infection, skin ulcer, dry skin^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth, constipation, gastroesophageal reflux, oropharyngeal candidiasis, dyspepsia, abdominal pain, vomiting
• Uncommon (0.1% to 1%): Dysphagia, gingivitis, intestinal obstruction including ileus paralytic, stomatitis (including ulcerative stomatitis)
• Rare (less than 0.1%): Dental caries, glossitis
• Frequency not reported: Nausea
• Postmarketing reports: Oral candidiasis, throat irritation, mouth ulceration^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection
• Uncommon (0.1% to 1%): Urinary retention, dysuria^[Ref]

Hypersensitivity

• Common (1% to 10%): Allergic reactions
• Rare (less than 0.1%): Angioedema, hypersensitivity (including immediate reactions)
• Frequency not reported: Anaphylactic reactions^[Ref]

Metabolic

• Common (1% to 10%): Hypercholesterolemia, hyperglycemia
• Frequency not reported: Dehydration^[Ref]

Musculoskeletal

• Common (1% to 10%): Myalgia, arthritis, skeletal pain, leg pain
• Frequency not reported: Join swelling^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, paresthesia
• Uncommon (0.1% to 1%): Headache, insomnia, taste disorder^[Ref]

Ocular

• Common (1% to 10%): Cataract
• Uncommon (0.1% to 1%): Blurred vision
• Rare (less than 0.1%): Glaucoma, intraocular pressure increased^[Ref]

Other

• Common (1% to 10%): Edema, infections, moniliasis, influenza-like symptoms, herpes zoster^[Ref]

Psychiatric

• Common (1% to 10%): Depression^[Ref]

Further information

Tiotropium side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer