Tarka Side Effects

Generic name: trandolapril / verapamil

Medically reviewed by Drugs.com. Last updated on Feb 20, 2024.

Note: This document provides detailed information about Tarka Side Effects associated with trandolapril / verapamil. Some dosage forms listed on this page may not apply specifically to the brand name Tarka.

Applies to trandolapril / verapamil: oral tablet extended release.

Important warnings This medicine can cause some serious health issues

Oral route (tablet, extended release)

Discontinue treatment with trandolapril/verapamil hydrochloride as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Serious side effects of Tarka

Along with its needed effects, trandolapril / verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril / verapamil:

Rare side effects

• chest pain
• chills
• cough (with mucus)
• dark urine
• fever
• general feeling of discomfort or illness
• lightheadedness or fainting
• pain in the right side of the abdomen or stomach
• slow heartbeat
• sore throat
• swelling of the face, mouth, hands, or feet
• trouble in swallowing or breathing (sudden) accompanied by hoarseness
• yellow eyes or skin

Other side effects of Tarka

Some side effects of trandolapril / verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare side effects

• constipation
• cough (dry, continuous)
• diarrhea
• dizziness
• itching
• joint pain or pain in the arms or legs
• nausea
• unusual tiredness

For healthcare professionals

Applies to trandolapril / verapamil: oral tablet extended release.

General adverse events

The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.^[Ref]

Respiratory

• Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion
• Frequency not reported: Epistaxis

Verapamil:

• Frequency not reported: Pulmonary edema^[Ref]

Other

• Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue
• Frequency not reported: Malaise

Verapamil:

• Frequency not reported: Gynecomastia^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, nausea, diarrhea
• Frequency not reported: Dyspepsia, dry mouth

Trandolapril:

• Frequency not reported: Pancreatitis

Verapamil:

• Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus^[Ref]

Musculoskeletal

• Common (1% to 10%): Pain back, pain extremity, pain joint
• Frequency not reported: Arthralgias/myalgias^[Ref]

Cardiovascular

• Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia
• Uncommon (0.1% to 1%): Hypotension
• Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia

Verapamil:

• Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Near syncope
• Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus

Verapamil:

• Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence
• Postmarketing reports: Tetraparesis^[Ref]

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.^[Ref]

Renal

• Common (1% to 10%): Creatinine increased
• Uncommon (0.1% to 1%): BUN increased^[Ref]

Metabolic

• Common (1% to 10%): Hyperlipidemia
• Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia^[Ref]

Hepatic

• Common (1% to 10%): Liver enzymes increased
• Frequency not reported: Serum bilirubin increased^[Ref]

Immunologic

• Common (1% to 10%): Influenza^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Angioedema
• Frequency not reported: Pruritus, rash

Verapamil:

• Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform^[Ref]

Genitourinary

• Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria

Verapamil:

• Frequency not reported: Urination increased, menstruation spotty^[Ref]

Hematologic

• Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low^[Ref]

Psychiatric

• Frequency not reported: Insomnia, anxiety, mentation abnormal

Trandolapril:

• Frequency not reported: Libido decreased

Verapamil:

• Frequency not reported: Confusion, psychotic symptoms^[Ref]

Ocular

• Frequency not reported: Vision blurred^[Ref]

Endocrine

Verapamil:

• Frequency not reported: Galactorrhea/hyperprolactinemia^[Ref]

Further information

Tarka side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer