Synvisc-One Side Effects

Generic name: hylan g-f 20

Medically reviewed by Drugs.com. Last updated on Jan 1, 2025.

Note: This document provides detailed information about Synvisc-One Side Effects associated with hylan g-f 20. Some dosage forms listed on this page may not apply specifically to the brand name Synvisc-One.

Applies to hylan g-f 20: solution.

Other dosage forms:

• injection injectable, injection solution

Serious side effects of Synvisc-One

Along with its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc-One) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hylan g-f 20:

More common side effects

• difficulty with moving
• fluid build up around the knee
• muscle pain or stiffness
• pain and stiffness in the joints

Less common side effects

• bleeding after defecation
• bluish color
• changes in skin color
• fainting
• fast, pounding, or irregular heartbeat or pulse
• pain or aching in the lower legs
• swelling of the ankles, feet, or legs
• tenderness
• uncomfortable swelling around the anus
• warmth or swelling of the joints

Rare side effects

• redness in the joints

Incidence not known

• black, tarry stools
• bleeding gums
• bloating or swelling of the face, arms, hands, lower legs, or feet
• blood in the urine or stools
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chills
• feeling of warmth
• general feeling of discomfort or illness
• muscle cramps
• pinpoint red spots on the skin
• rapid weight gain
• redness of the face, neck, arms, and occasionally, upper chest
• tingling of the hands or feet
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss

Other side effects of Synvisc-One

Some side effects of hylan g-f 20 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• itching of the skin
• rash
• sprain in the lower back

Rare side effects

• pain at the injection site

Incidence not known

• dizziness
• headache
• nausea
• raised red swellings on the skin, lips, tongue, or in the throat

For healthcare professionals

Applies to hylan g-f 20: intra-articular solution.

Dermatologic adverse events

• Frequency not reported: Rash, itching, hives, itching, face swelling, generalized urticaria^[Ref]

Gastrointestinal

• Frequency not reported: Hemorrhoids, nausea, tonsillitis^[Ref]

Musculoskeletal

• Frequency not reported: Low back sprain, calf cramps, muscle cramps
• Postmarketing reports: Acute inflammation (e.g., joint pain, swelling, effusion, joint warmth and/or stiffness)^[Ref]

Cardiovascular

• Frequency not reported: Tachyarrhythmia, phlebitis with varicosities, flushing^[Ref]

Nervous system

• Frequency not reported: Headache, dizziness, chills, paresthesia^[Ref]

Respiratory

• Frequency not reported: Respiratory difficulty^[Ref]

Hypersensitivity

• Frequency not reported: Synovial eosinophilia^[Ref]

Local

• Postmarketing reports: Injection site pain, injection site swelling^[Ref]

Hematologic

• Rare (less than 0.1%): Thrombocytopenia^[Ref]

Other

• Frequency not reported: Ankle edema, fever, peripheral edema, malaise^[Ref]

Further information

Synvisc-One side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer