Sunlenca Side Effects

Generic name: lenacapavir

Medically reviewed by Drugs.com. Last updated on Feb 21, 2025.

Note: This document provides detailed information about Sunlenca Side Effects associated with lenacapavir. Some dosage forms listed on this page may not apply specifically to the brand name Sunlenca.

Applies to lenacapavir: oral tablet.

Other dosage forms:

• subcutaneous solution

Serious side effects of Sunlenca

Along with its needed effects, lenacapavir (the active ingredient contained in Sunlenca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lenacapavir:

Incidence not known

• dark urine
• fever
• inability to move the arms and legs
• joint pain
• light-colored stools
• muscle tenderness, weakness, or pain
• nausea and vomiting
• skin rash
• sudden numbness and weakness in the arms and legs
• unusual tiredness or weakness
• upper right abdominal or stomach pain
• weight loss
• yellow eyes and skin

For healthcare professionals

Applies to lenacapavir: oral tablet, subcutaneous solution.

General adverse events

The most common adverse reactions reported in at least 3% patients were nausea and injection site reactions.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea^[Ref]

Hepatic

• Common (1% to 10%): Increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased direct bilirubin^[Ref]

Local

• Very common (10% or more): Injection site reactions (65%) [include swelling (36%), pain (31%), erythema (31%), nodule (25%), induration (15%), pruritus (6%), extravasation (3%) discomfort (1%), mass (3%), hematoma (1%), edema (1%) and ulcer (1%)]^[Ref]

Four percent patients experienced Grade 3 ISRs (erythema, pain, swelling)^[Ref]

Metabolic

• Common (1% to 10%): Glycosuria, hyperglycemia, proteinuria^[Ref]

Musculoskeletal

• Very common (10% or more): Increased creatinine (13%)^[Ref]

Further information

Sunlenca side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer