Sirolimus Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 4, 2025.

Applies to sirolimus topical: topical application gel/jelly.

Serious side effects of sirolimus topical

Along with its needed effects, sirolimus topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sirolimus topical:

More common side effects

• blemishes on the skin
• burning, itching, redness, skin rash, swelling, or soreness at the application site
• dry skin
• pimples

Less common side effects

• redness of the eye
• redness or stinging of the skin

Incidence not known

• back pain
• black, tarry stools
• blurred vision
• chest pain or tightness
• confusion
• cough
• cracks in the skin
• difficulty breathing
• difficulty swallowing
• dizziness
• drowsiness
• fast heartbeat
• fever
• general feeling of illness
• headache
• hives, itching, skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of heat from the body
• persistent non-healing sore
• pink growth
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red, swollen skins
• reddish patch or irritated area
• scaly skin
• seizures
• shiny bump
• swollen glands
• thickening of bronchial secretions
• unusual tiredness or weakness
• weight loss
• white, yellow or waxy scar-like area
• yellow skin and eyes

For healthcare professionals

Applies to sirolimus topical: topical gel.

Dermatologic adverse events

• Very common (10% or more): Dry skin (40%), pruritus (17%)
• Common (1% to 10%): Acne, acneiform dermatitis, contact dermatitis, erythema, photosensitivity reaction, skin hemorrhage, skin irritation, solar dermatitis^[Ref]

Local

• Very common (10% or more): Application site irritation (37%)^[Ref]

Ocular

• Common (1% to 10%): Eye irritation, ocular hyperemia^[Ref]

Further information

Sirolimus topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer