Siliq Side Effects

Generic name: brodalumab

Medically reviewed by Drugs.com. Last updated on Sep 14, 2024.

Note: This document provides detailed information about Siliq Side Effects associated with brodalumab. Some dosage forms listed on this page may not apply specifically to the brand name Siliq.

Applies to brodalumab: subcutaneous solution.

Important warnings This medicine can cause some serious health issues

Subcutaneous route (solution)

Suicidal ideation and behavior, including completed suicides, have occurred with brodalumab.

Weigh potential risks and benefits in each patient prior to initiation, and advise patients and caregivers to seek medical attention for new or worsening depression, anxiety, or other mood changes.

Refer patients with new or worsening suicidal ideation and behavior to a mental health professional.

Brodalumab is only available through a restricted program called the Siliq REMS Program.

Serious side effects of Siliq

Along with its needed effects, brodalumab (the active ingredient contained in Siliq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Less common side effects

• black, tarry stools
• chills
• cough
• diarrhea
• fever
• general feeling of discomfort or illness
• headache
• joint pain
• loss of appetite
• lower back or side pain
• muscle aches and pains
• nausea
• painful or difficult urination
• pale skin
• runny nose
• shivering
• sore throat
• sweating
• trouble sleeping
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting

Incidence not known

• changes in behavior
• discouragement
• feeling sad or empty
• irritability
• lack of appetite
• loss of interest or pleasure
• thoughts of killing oneself
• trouble concentrating
• trouble sleeping

Other side effects of Siliq

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• difficulty with moving
• muscle pain or stiffness
• pain in the joints
• pain, redness, burning, or itching at the injection site

For healthcare professionals

Applies to brodalumab: subcutaneous solution.

Gastrointestinal adverse events

• Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea^[Ref]

Hematologic

• Common (1% to 10%): Neutropenia^[Ref]

Genitourinary

• Frequency not reported: Urinary tract infection^[Ref]

Other

• Common (1% to 10%): Fatigue^[Ref]

Immunologic

• Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity
• Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)^[Ref]

Local

• Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, myalgia^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Ocular

• Uncommon (0.1% to 1%): Conjunctivitis^[Ref]

Respiratory

• Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Suicidal ideation or behavior^[Ref]

Frequently asked questions

• What are the new drugs for plaque psoriasis?
• What is the Siliq REMS Program?

Further information

Siliq side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer