Levemir Side Effects

Generic name: insulin detemir

Medically reviewed by Drugs.com. Last updated on Nov 25, 2024.

Note: This document provides detailed information about Levemir Side Effects associated with insulin detemir. Some dosage forms listed on this page may not apply specifically to the brand name Levemir.

Applies to insulin detemir: subcutaneous solution.

Serious side effects of Levemir

Along with its needed effects, insulin detemir (the active ingredient contained in Levemir) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking insulin detemir:

Incidence not known

• anxiety
• blurred vision
• chest tightness
• chills
• cold sweats
• confusion
• cool, pale skin
• cough
• depression
• difficulty swallowing
• dizziness
• fast heartbeat
• fever
• headache
• hives, itching, or skin rash
• hoarseness
• increased hunger
• irritation
• joint pain
• nausea
• nightmares
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness of the skin
• seizures
• shakiness
• slurred speech
• stiffness or swelling
• swelling of the eyelids, face, lips, hands, or feet
• trouble breathing
• unusual tiredness or weakness

Other side effects of Levemir

Some side effects of insulin detemir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• decrease in the amount of urine
• noisy, rattling breathing
• redistribution or accumulation of body fat
• swelling of the fingers, hands, feet, or lower legs
• trouble breathing at rest
• weight gain

For healthcare professionals

Applies to insulin detemir: subcutaneous solution.

General adverse events

Adverse reactions associated with insulin detemir (the active ingredient contained in Levemir) include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, rash, and pruritus.^[Ref]

Metabolic

• Very common (10% or more): Hypoglycemia
• Frequency not reported: Weight gain^[Ref]

Severe hypoglycemia defined as third party intervention, occurred in approximately 6% of patients receiving insulin detemir (the active ingredient contained in Levemir) in clinical trials. Weight gain has been reported with insulin therapy and has been attributed to the anabolic effects of insulin and the decrease in glucosuria.^[Ref]

Local

• Common (1% to 10%): Injection site reactions
• Uncommon (0.1% to 1%): Injection site pain^[Ref]

Injection site reactions seem to occur more frequently with insulin detemir than with human insulin products. Reactions have included pain, redness, hives, inflammation, bruising, swelling, and itching at the injection site. Most injection site reactions have been minor and transitory, disappearing in a few days to a few weeks, even with continued treatment.^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Allergic reactions^[Ref]

Hypersensitivity side effects have included both local and systemic reactions. Anaphylaxis has been reported. Local reactions have presented as erythema, local edema, and pruritus at the injection site. Most minor reactions to insulin at the injection site resolve in a few days to a few weeks.

Allergic reactions and potentially allergic reactions were reported more frequently in 3 clinical studies with subjects receiving combination oral antidiabetic agents compared with the frequency across all studies (2.2% versus 0.1% to 1%).^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Peripheral edema^[Ref]

Insulin may cause sodium retention and edema, especially as metabolic control is improving.^[Ref]

Ocular

• Frequency not reported: Refraction disorder, worsening of diabetic retinopathy^[Ref]

Rapid improvement in glucose control has been associated with a transitory, reversible ophthalmologic refraction disorder and worsening of diabetic retinopathy. However, long-term glycemic control decreases the risk of diabetic retinopathy.^[Ref]

Dermatologic

• Common (1% to 10%): Lipohypertrophy
• Uncommon (0.1% to 1%): Lipoatrophy
• Postmarketing reports: Rash urticaria^[Ref]

Immunologic

• Very common (10% or more): Influenza-like illness (up to 13%)
• Common (1% to 10%): Viral infection
• Frequency not reported: Antibody development^[Ref]

In phase 3 trials, antibody development with no apparent impact on glycemic control was observed.^[Ref]

Other

• Common (1% to 10%): Pyrexia, fatigue^[Ref]

Gastrointestinal

• Very common (10% or more): Gastroenteritis (up to 16%), abdominal pain (up to 13%)
• Common (1% to 10%): Nausea, vomiting, toothache^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 31%)
• Common (1% to 10%): Migraine, dizziness
• Rare (less than 0.1%): Painful peripheral neuropathy^[Ref]

Rapid improvement in glucose control has been associated with a transitory, reversible acute painful peripheral neuropathy. However, long-term glycemic control decreases the risk.^[Ref]

Respiratory

• Very common (10% or more): Upper respiratory tract infection (up to 35%), pharyngitis (up to 17%)
• Common (1% to 10%): Bronchitis, cough, rhinitis, sinusitis^[Ref]

Frequently asked questions

• Levemir vs Lantus: What's the difference?
• Which type of insulin has the longest duration of action?
• How and where should I inject insulin?

Further information

Levemir side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer