Lanreotide Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 15, 2024.

Applies to lanreotide: subcutaneous solution.

Serious side effects of lanreotide

Along with its needed effects, lanreotide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanreotide:

More common side effects

• blurred vision
• chest pain or discomfort
• dizziness
• gaseous abdominal or stomach pain
• headache
• lightheadedness, dizziness, or fainting
• nervousness
• pale skin
• pounding in the ears
• recurrent fever
• slow, fast, or irregular heartbeat
• stomach fullness
• troubled breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow eyes or skin

Incidence not known

• bloating
• chills
• clay-colored stools
• confusion
• constipation
• cough
• dark urine
• diarrhea
• difficulty swallowing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fat in the stool
• fever
• hives, itching, skin rash
• indigestion
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
• loss of appetite
• nausea
• pains in the stomach, side, or abdomen, possibly radiating to the back
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• severe nausea or vomiting
• stomach pain or cramps
• sudden loss of weight
• sweating
• tightness in the chest
• unusual drowsiness, dullness, or feeling of sluggishness
• vomiting

Other side effects of lanreotide

Some side effects of lanreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• difficulty having a bowel movement
• difficulty with moving
• excess air or gas in the stomach or bowels
• feeling of fullness
• inflammation, itching, lumps, or pain at the injection site
• muscle pain or stiffness
• pain in the joints
• passing gas
• weight loss

For healthcare professionals

Applies to lanreotide: subcutaneous solution.

General adverse events

The most common adverse events were gastrointestinal disorders, cholelithiasis, and injection site reactions.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 65%), abdominal pain (34%), vomiting (19%), flatulence (14%), nausea (11%), loose stools
• Common (1% to 10%): Constipation, flatulence, abdominal distension, abdominal discomfort, dyspepsia
• Uncommon (0.1% to 1%): Pancreatitis, feces discolored
• Frequency not reported: Steatorrhea^[Ref]

In one of the studies, diarrhea, abdominal pain, and flatulence increased as the dose increased.^[Ref]

Hepatic

• Very common (10% or more): Cholelithiasis (27%), bladder sludge (20%), new cholelithiasis
• Common (1% to 10%): ALT increased, AST abnormal, ALT abnormal, blood bilirubin increased, biliary dilatation
• Uncommon (0.1% to 1%): AST increased, blood alkaline phosphatase increased, blood bilirubin abnormal
• Frequency not reported: Cholecystitis
• Postmarketing reports: Steatorrhea, pancreatitis^[Ref]

Cardiovascular

• Very common (10% or more): Bradycardia (18%), hypertension (14%)
• Common (1% to 10%): Sinus bradycardia
• Uncommon (0.1% to 1%): Other cardiac adverse drug reactions^[Ref]

Local

• Very common (10% or more): Application site disorder (injection site mass/pain/reaction/inflammation/ nodule/pruritus, 30%)
• Postmarketing reports: Persisting induration, injection site abscess^[Ref]

Metabolic

• Very common (10% or more): Dysglycemia (hypoglycemia, hyperglycemia, diabetes, 14%), weight decrease (11%)
• Common (1% to 10%): Blood glucose increased, glycosylated hemoglobin increased
• Uncommon (0.1% to 1%): Blood sodium decreased, diabetes mellitus aggravated^[Ref]

Hematologic

• Very common (10% or more): Anemia (14%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (19%), arthralgia (11%)^[Ref]

Nervous system

• Very common (10% or more): Headache (16%)
• Common (1% to 10%): Dizziness
• Postmarketing reports: Dysautonomia^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea^[Ref]

Psychiatric

• Common (1% to 10%): Depression
• Uncommon (0.1% to 1%): Insomnia^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Hot flush, asthenia
• Postmarketing reports: Malaise^[Ref]

Immunologic

• Common (1% to 10%): Anti-lanreotide antibodies^[Ref]

Hypersensitivity

• Frequency not reported: Allergic reactions (including angioedema, anaphylaxis, and hypersensitivity)^[Ref]

Dermatologic

• Common (1% to 10%): Alopecia, hypotrichosis^[Ref]

Endocrine

• Rare (less than 0.1%): Clinical hypothyroidism
• Frequency not reported: Slight decreases in thyroid function^[Ref]

Further information

Lanreotide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer