Jaypirca Side Effects

Generic name: pirtobrutinib

Medically reviewed by Drugs.com. Last updated on Nov 23, 2023.

Note: This document provides detailed information about Jaypirca Side Effects associated with pirtobrutinib. Some dosage forms listed on this page may not apply specifically to the brand name Jaypirca.

Applies to pirtobrutinib: oral tablet.

Serious side effects of Jaypirca

Along with its needed effects, pirtobrutinib (the active ingredient contained in Jaypirca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pirtobrutinib:

More common side effects

• black, tarry stools
• bleeding gums
• blood in the urine or stools
• body aches or pain
• chest pain or tightness
• cough
• ear congestion
• fever or chills
• loss of voice
• pale skin
• pinpoint red spots on the skin
• sneezing
• sore throat
• stuffy or runny nose
• swelling
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common side effects

• confusion
• dizziness
• fainting
• fast or irregular heartbeat
• lightheadedness
• lower back or side pain
• painful or difficult urination
• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• shiny bump
• ulcers, sores, or white spots in the mouth
• white, yellow, or waxy scar-like area

Other side effects of Jaypirca

Some side effects of pirtobrutinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• burning, numbness, tingling, or painful sensations
• constipation
• cough
• diarrhea
• difficulty in moving
• joint pain
• large, flat, blue or purplish patches in the skin
• muscle or bone pain
• muscle stiffness
• nausea
• pain, swelling, or redness in the joints
• stomach pain
• unsteadiness or awkwardness
• weakness in the arms, hands, legs, or feet

For healthcare professionals

Applies to pirtobrutinib: oral tablet.

General adverse events

The most common adverse reactions reported were decreased neutrophils, hemoglobin, platelets, and lymphocytes, as well as fatigue, musculoskeletal pain, bruising, diarrhea, edema, dyspnea, and pneumonia.^[Ref]

Dermatologic

• Very common (10% or more): Rash (14%)^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (19%), constipation (13%), abdominal pain (11%), nausea (11%)^[Ref]

Hematologic

• Very common (10% or more): Hemorrhage (11%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (27%), arthritis/arthralgia (up to 12%)^[Ref]

Nervous system

• Very common (10% or more): Peripheral neuropathy (14%), dizziness (10%)
• Frequency not reported: Memory changes, headache^[Ref]

Ocular

• Frequency not reported: Vision changes^[Ref]

Oncologic

• Frequency not reported: Tumor lysis syndrome^[Ref]

Other

• Very common (10% or more): Fatigue (29%), edema (18%), fever (13%), pneumonia (16%), upper respiratory tract infections (10%), bruising (16%), decreased hemoglobin (42%), decreased platelet count (39%), decreased neutrophil count (36%), decreased lymphocyte count (32%), increased creatinine (30%), decreased calcium (19%), increased aspartate aminotransferase (AST) (17%), increased alanine transaminase (ALT) (11%), decreased potassium (13%), increased potassium (11%), decreased sodium (13%), increased lipase (12%), increased alkaline phosphatase (11%)
• Common (1% to 10%): Sepsis (2.3%)
• Frequency not reported: Urinary tract infection, herpes virus infection^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (17%), cough (14%)
• Common (1% to 10%): Pleural effusion (2.3%)^[Ref]

Frequently asked questions

• How long does it take for Jaypirca to work?

Further information

Jaypirca side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer