Jardiance Side Effects
Generic name: empagliflozin
Note: This document contains side effect information about empagliflozin. Some dosage forms listed on this page may not apply to the brand name Jardiance.
Applies to empagliflozin: oral tablet.
Serious side effects of Jardiance
Along with its needed effects, empagliflozin (the active ingredient contained in Jardiance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking empagliflozin:
More common
- Bladder pain
- bloody or cloudy urine
- change in the color, amount, or odor of vaginal discharge
- difficult, burning, or painful urination
- frequent urge to urinate
- itching, stinging, or redness of the vaginal area
- lower back or side pain
- pain during sexual intercourse
Less common
- Discharge with a strong odor from the penis
- increased volume of pale, dilute urine
- redness, itching, swelling, or pain around the penis
- waking to urinate at night
Rare
- Anxiety
- blurred vision
- chills
- cold sweats
- confusion
- decreased urination
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast heartbeat
- headache
- increased hunger
- nausea
- nightmares
- rapid breathing
- seizures
- shakiness
- slurred speech
- sweating
- unusual tiredness or weakness
Incidence not known
- Dry mouth
- fever
- flushed, dry skin
- fruit-like breath odor
- increased thirst
- itching, skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- loss of appetite
- loss of consciousness
- pain, tenderness, redness, or swelling of the area between the anus and genitals
- redness of the skin
- stomach pain
- sunken eyes
- trouble breathing
- unexplained weight loss
- vomiting
- weight gain
- wrinkled skin
Other side effects of Jardiance
Some side effects of empagliflozin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Body aches or pain
- cough
- loss of voice
- muscle pain or stiffness
- runny or stuffy nose
- sneezing
For Healthcare Professionals
Applies to empagliflozin: oral tablet.
General
The most common adverse reactions (incidence of greater than 5%) were urinary tract infections, female genital mycotic infections, hypoglycemia, and adverse reactions related to volume depletion. Pediatric patients experienced a higher incidence of hypoglycemia.[Ref]
Cardiovascular
Postmarketing reports: Hypotension
Dermatologic
Common (1% to 10%): Pruritus, rash
Postmarketing reports: Skin reactions including angioedema and urticaria
Gastrointestinal
Common (1% to 10%): Nausea
Postmarketing reports: Constipation
Genitourinary
Very common (10% or more): Female urinary tract infections (up to 18.4%)
Common (1% to 10%): Female genital mycotic infections, increased urination, male urinary tract infections
Uncommon (0.1% to 1%): Phimosis, male genital mycotic infections, nocturia, dysuria
Postmarketing reports: Urosepsis, pyelonephritis, necrotizing fasciitis of the perineum (Fournier's gangrene)
Hematologic
Common (1% to 10%): Increased hematocrit
Hepatic
Frequency not reported: Hepatic injury
Hypersensitivity
Postmarketing reports: Angioedema, hypersensitivity reactions
Metabolic
Very common (10% or more): Hypoglycemia, especially in combination with other glucose lowering therapies (up to 41.3%), adverse reactions related to volume depletion (up to 11.4%)
Common (1% to 10%): Increased low-density lipoprotein cholesterol, dyslipidemia
Postmarketing reports: Ketoacidosis
The risk of hypoglycemia (i.e., blood glucose less than 54 mg/dL) was higher in pediatric patients.
Reactions related to volume depletion included decreased ambulatory blood pressure, decreased systolic blood pressure, dehydration, hypotension, hypovolemia, orthostatic hypotension, and syncope with the highest rates occurring in patients with heart failure.
In clinical studies, ketoacidosis was not immediately recognized, especially in patients with type 1 diabetes, and treatment was delayed because presenting blood glucose levels were lower (often less than 250 mg/dL [14 mmol/l]) than those typically expected. In some, but not all cases, patients had an identifiable precipitating risk factor for ketoacidosis
Musculoskeletal
Common (1% to 10%): Arthralgia
Other
Common (1% to 10%): Thirst
Frequency not reported: Lower limb amputation
Renal
Very rare (less than 0.01%): Tubulo-interstitial nephritis
Frequency not reported: Increased serum creatinine, decreased estimated GFR
Postmarketing reports: Acute kidney injury, urosepsis, pyelonephritis
Respiratory
Common (1% to 10%): Upper respiratory tract infection
Frequently asked questions
- How to avoid yeast infections on Jardiance?
- Does Jardiance cause weight loss?
- How long does it take for Jardiance to work?
- What does Jardiance do to your perineum?
- What is Jardiance used for and how does it work?
- When is the best time of day to take it?
More about Jardiance (empagliflozin)
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- Drug class: SGLT-2 inhibitors
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References
1. (2023) "Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim Ltd
2. (2023) "Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim, SUPPL-42
3. (2024) "Product Information. Jardiance (empagliflozin)." Boehringer Ingelheim Pty Ltd
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.