Iron Chews Side Effects
Generic name: carbonyl iron
Medically reviewed by Drugs.com. Last updated on Apr 5, 2024.
Note: This document provides detailed information about Iron Chews.
For healthcare professionals
Applies to carbonyl iron: oral suspension, oral tablet, oral tablet chewable.
Gastrointestinal
Gastrointestinal side effects have been reported the most frequently. They have included diarrhea (45%) vs. placebo (3%), cramping (38%) vs. placebo (0%), nausea (30%) vs. placebo (8%), constipation (25%) vs. placebo (14%), heartburn (17%) vs. placebo (6%), and epigastric discomfort (16%) vs. placebo (11%).[Ref]
Constipation may be relieved by administering docusate sodium 100 mg to 200 mg per day in addition to increasing the intake of oral fluids, such as water.[Ref]
Other
Other side effects have included iron overload (hemosiderosis) and stained teeth. Secondary hemochromatosis due to prolonged iron ingestion has been reported rarely. An unpleasant taste following carbonyl iron (the active ingredient contained in Iron Chews) ingestion has been reported in 40% to 70% of patients.[Ref]
Iron overload (i.e., hemosiderosis) has been reported in patients genetically predisposed, or have underlying disorders, that augment the absorption of iron. It has also occurred following administration of excessive parenteral iron therapy, combination of oral and parenteral iron, or in patients with hemoglobinopathies that were erroneously diagnosed as iron deficiency anemia. Hemosiderosis is treated with repeated phlebotomy or long-term administration of deferoxamine. The liver is particularly susceptible to toxicity in iron-overload states Side Effects associated with carbonyl iron. Some dosage forms listed on this page may not apply specifically to the brand name Iron Chews.
For healthcare professionals
Applies to carbonyl iron: oral suspension, oral tablet, oral tablet chewable.
Gastrointestinal
Gastrointestinal side effects have been reported the most frequently. They have included diarrhea (45%) vs. placebo (3%), cramping (38%) vs. placebo (0%), nausea (30%) vs. placebo (8%), constipation (25%) vs. placebo (14%), heartburn (17%) vs. placebo (6%), and epigastric discomfort (16%) vs. placebo (11%).[Ref]
Constipation may be relieved by administering docusate sodium 100 mg to 200 mg per day in addition to increasing the intake of oral fluids, such as water.[Ref]
Other
Other side effects have included iron overload (hemosiderosis) and stained teeth. Secondary hemochromatosis due to prolonged iron ingestion has been reported rarely. An unpleasant taste following carbonyl iron (the active ingredient contained in Iron Chews) ingestion has been reported in 40% to 70% of patients.[Ref]
Iron overload (i.e., hemosiderosis) has been reported in patients genetically predisposed, or have underlying disorders, that augment the absorption of iron. It has also occurred following administration of excessive parenteral iron therapy, combination of oral and parenteral iron, or in patients with hemoglobinopathies that were erroneously diagnosed as iron deficiency anemia. Hemosiderosis is treated with repeated phlebotomy or long-term administration of deferoxamine. The liver is particularly susceptible to toxicity in iron-overload states.
Stained teeth have been reported primarily following ingestion of iron liquid preparations. Liquid dosage forms should be diluted in juice or water and sipped through a straw to aid in prevention of staining.[Ref]
Nervous system
Nervous system side effects have included headache (29%) vs. placebo (25%), and weakness (11%) vs placebo (9%).[Ref]
References
1. Gordeuk VR, Brittenham GM, Hughes M, Keating LJ, Opplt JJ (1987) "High-dose carbonyl iron for iron deficiency anemia: a randomized double-blind trial." Am J Clin Nutr, 46, p. 1029-34
2. Gordeuk VR, Brittenham GM, McLaren CE, Hughes MA, Keating LJ (1986) "Carbonyl iron therapy for iron deficiency anemia." Blood, 67, p. 745-52
3. Devasthali SD, Gordeuk VR, Brittenham GM, Bravo JR, Hughes MA, Keating LJ (1991) "Bioavailability of carbonyl iron: a randomized, double-blind study." Eur J Haematol, 46, p. 272-8
4. Gordeuk VR, Brittenham GM, Hughes MA, Keating LJ (1987) "Carbonyl iron for short-term supplementation in female blood donors." Transfusion, 27, p. 80-5
5. "Product Information. Feosol Caplet (carbonyl iron)." SmithKline Beecham
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Iron Chews side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.