Hydrochlorothiazide / Propranolol Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 11, 2024.

Applies to hydrochlorothiazide / propranolol: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Following abrupt cessation of therapy with propranolol, exacerbations of angina pectoris and, in some cases, myocardial infarction have been reported.

Even in the absence of overt angina pectoris, when discontinuing therapy, propranolol should not be withdrawn abruptly, and patients should be cautioned against interruption of therapy without the physician's advice.

Serious side effects

Along with its needed effects, hydrochlorothiazide/propranolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / propranolol:

Incidence not known

• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• blood in the urine
• bloody nose
• bloody stools
• blurred or loss of vision
• body aches or pain
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain, discomfort, or tightness
• clay-colored stools
• cold sweats
• confusion about identity, place, and time
• congestion
• constipation
• cough
• coughing up blood
• cracks in the skin
• crying
• darkened urine
• decreased awareness or responsiveness
• decreased urine output
• depersonalization
• diarrhea
• difficulty with breathing or swallowing
• dilated neck veins
• disturbed color perception
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• double vision
• dry mouth
• dryness or soreness of the throat
• dysphoria
• false or unusual sense of well-being
• fast, pounding, slow, or irregular heartbeat
• fever or chills
• flushing or redness of the skin
• fruit-like breath odor
• general feeling of discomfort or illness
• general feeling of tiredness or weakness
• hair loss
• halos around lights
• headaches
• heavier menstrual periods
• hives or welts, itching
• hoarseness
• increased hunger
• increased sensitivity of the skin to sunlight
• increased thirst
• increased urination
• indigestion
• irregular breathing
• irregular heartbeat
• joint pain, stiffness, or swelling
• lightheadedness, dizziness, or fainting
• loss of appetite
• loss of heat from the body
• loss of strength or energy
• lower back or side pain
• mental depression
• mimicry of speech or movements
• muscle pain or weakness
• mutism
• nausea or vomiting
• negativism
• night blindness
• noisy breathing
• overbright appearance of lights
• painful or difficult urination
• pains in the stomach, side, or abdomen, possibly radiating to the back
• paleness or cold feeling in the fingertips and toes
• paranoia
• peculiar postures or movements, mannerisms or grimacing
• persistent non-healing sore
• pink growth
• pinpoint red or purple spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• quick to react or overreact emotionally
• rapidly changing moods
• rectal bleeding
• red skin lesions, often with a purple center
• red, irritated eyes
• red, swollen skin
• reddening of the skin, especially around the ears
• reddish patch or irritated area
• runny nose
• scaly skin
• seeing, hearing, or feeling things that are not there
• severe sleepiness
• severe sunburn
• shiny bump
• short-term memory loss
• skin irritation or rash, including rash that looks like psoriasis
• sleeplessness
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain or tenderness
• sugar in the urine
• sweating
• swelling of the eyes, face, or inside of the nose
• swelling of the fingers, feet, or lower legs
• tender, swollen, or painful glands in the neck
• tenderness of salivary glands
• tenderness, burning, or peeling of the skin
• thickening of bronchial secretions
• tingling or pain in the fingers or toes when exposed to cold
• trouble breathing
• trouble with sleeping
• trouble with swallowing
• tunnel vision
• unable to sleep
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• unusually warm skin
• voice changes
• vomiting of blood
• weight gain
• white, yellow or waxy scar-like area
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrochlorothiazide / propranolol:

Symptoms of overdose

• change in consciousness
• decreased urination
• fast, slow, or shallow breathing
• gas
• heartburn
• increase in heart rate
• increased sweating
• indigestion
• loss of consciousness
• low blood pressure
• muscle cramps
• pale or blue lips, fingernails, or skin
• rapid breathing
• seizures
• sunken eyes
• unusual drowsiness, dullness, or feeling of sluggishness
• unusual paleness
• weakness and heaviness of the legs
• wrinkled skin

Other side effects

Some side effects of hydrochlorothiazide / propranolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• decreased interest in sexual intercourse
• dry eyes
• feeling of constant movement of self or surroundings
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• muscle spasm
• pain of the penis on erection
• pain or discomfort in the chest, upper stomach, or throat
• restlessness
• sensation of spinning
• stomach cramps
• thinning of the hair
• vivid dreams

For healthcare professionals

Applies to hydrochlorothiazide / propranolol: oral capsule extended release, oral tablet.

Cardiovascular adverse events

Hydrochlorothiazide:

• Frequency not reported: Orthostatic hypotension, vasculitis

Propranolol:

• Frequency not reported: Congestive heart failure, hypotension, intensification of atrioventricular block, bradycardia, arterial insufficiency^[Ref]

Dermatologic

Hydrochlorothiazide:

• Frequency not reported: Cutaneous vasculitis, urticaria, rash, photosensitivity, purpura, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis

Propranolol:

• Frequency not reported: Erythematous rash, alopecia, psoriasiform rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, urticaria^[Ref]

Gastrointestinal

Hydrochlorothiazide:

• Frequency not reported: Pancreatitis, sialadenitis, nausea, vomiting, gastric irritation, cramping, diarrhea, constipation

Propranolol:

• Frequency not reported: Mesenteric arterial thrombosis, ischemic colitis, nausea, vomiting, epigastric distress, abdominal cramping, diarrhea, constipation^[Ref]

Genitourinary

Hydrochlorothiazide:

• Frequency not reported: Glycosuria

Propranolol:

• Frequency not reported: Male impotence, Peyronie's disease^[Ref]

Hematologic

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia

Propranolol:

• Frequency not reported: Thrombocytopenic purpura, agranulocytosis, non-thrombocytopenic purpura, alkaline phosphatase increased, lactate dehydrogenase increased^[Ref]

Immunologic

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions

Propranolol:

• Frequency not reported: Hypersensitivity reactions, anaphylactic/anaphylactoid reactions^[Ref]

Metabolic

Hydrochlorothiazide:

• Frequency not reported: Anorexia, hyperglycemia, hyperuricemia

Propranolol:

• Frequency not reported: Serum potassium increased, blood urea increased^[Ref]

Musculoskeletal

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm

Propranolol:

• Frequency not reported: Systemic lupus erythematosus, lupus erythematosus-like reactions^[Ref]

Nervous system

Hydrochlorothiazide:

• Frequency not reported: Dizziness, vertigo, headache, paresthesias

Propranolol:

• Frequency not reported: Paresthesia of hands, short-term memory loss, slightly clouded sensorium, decreased performance on neuropsychometrics, lightheadedness, lethargy^[Ref]

Ocular

Hydrochlorothiazide:

• Frequency not reported: Xanthopsia, transient blurred vision

Propranolol:

• Frequency not reported: Visual disturbances, dry eyes^[Ref]

Other

Hydrochlorothiazide:

• Frequency not reported: Fever, weakness

Propranolol:

• Frequency not reported: Lassitude, weakness, fatigue, fever, aching^[Ref]

Psychiatric

Hydrochlorothiazide:

• Frequency not reported: Restlessness

Propranolol:

• Frequency not reported: Reversible mental depression progressing to catatonia, mental depression manifested by insomnia, an acute reversible syndrome characterized by disorientation for time and place, emotional lability, hallucinations, vivid dreams^[Ref]

Respiratory

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis

Propranolol:

• Frequency not reported: Laryngospasm, respiratory distress, pharyngitis, sore throat, bronchospasm^[Ref]

Hepatic

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice

Propranolol:

• Frequency not reported: Serum transaminase increased^[Ref]

Further information

Hydrochlorothiazide/propranolol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer