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Encorafenib Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 10, 2023.

Applies to encorafenib: oral capsule.

Serious side effects of encorafenib

Along with its needed effects, encorafenib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking encorafenib:

More common

  • black, tarry stools
  • bleeding gums
  • bloating
  • blood in the urine or stools
  • chest pain or tightness
  • chills
  • constipation
  • coughing up blood
  • dark urine
  • difficulty in breathing or swallowing
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • hives, itching, skin rash
  • hoarseness
  • increased menstrual flow or vaginal bleeding
  • indigestion
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • lower back or side pain
  • nausea
  • nosebleed
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • partial or slight paralysis of the face
  • pinpoint red spots on the skin
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark-brown urine
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • sore throat
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen glands
  • thickening of the skin
  • tingling of the hands and feet
  • ulcers, sores, or white spots in the mouth
  • ulceration of the skin
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Rare

  • vomiting of blood or material that looks like coffee grounds

Other side effects of encorafenib

Some side effects of encorafenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • back pain
  • burning, numbness, tingling, or painful sensations
  • change in taste
  • difficulty in moving
  • dry skin
  • hair loss, thinning of hair
  • loss of taste
  • muscular pain, tenderness, wasting, or weakness
  • pain in the arms or legs
  • stomach pain
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For healthcare professionals

Applies to encorafenib: oral capsule.

Hematologic

Hypersensitivity

Musculoskeletal

Ocular

Metabolic

Hepatic

Oncologic

Other

Nervous system

Renal

Cardiovascular

Dermatologic

Gastrointestinal

Psychiatric

References

1. (2018) "Product Information. Braftovi (encorafenib)." Array BioPharma Inc.

Frequently asked questions

Further information

Encorafenib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.