Embeda Side Effects
Generic name: morphine / naltrexone
Medically reviewed by Drugs.com. Last updated on May 9, 2024.
Note: This document provides detailed information about Embeda.
Applies to morphine / naltrexone: oral capsule extended release Side Effects associated with morphine / naltrexone. Some dosage forms listed on this page may not apply specifically to the brand name Embeda.
Applies to morphine / naltrexone: oral capsule extended release.
Important warnings
This medicine can cause some serious health issues
Serious side effects of Embeda
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Trouble breathing, slow breathing, or shallow breathing.
- Shortness of breath.
- Very bad dizziness or passing out.
- Seizures.
- Very upset stomach or throwing up.
- Very bad constipation.
- Chest pain or pressure or a fast heartbeat.
- Feeling very sleepy.
- Noisy breathing.
- Feeling confused.
- Very bad belly pain.
- Long-term use of an opioid drug may lead to lower sex hormone levels. Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period (women), or change in sex ability (men).
- A severe and sometimes deadly problem called serotonin syndrome may happen if you take this drug with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.
- Taking an opioid drug like this drug may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
Other side effects of Embeda
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.
- Headache.
- Feeling sleepy.
- Dizziness.
- Upset stomach or throwing up.
- Constipation.
- Dry mouth.
- Itching.
- Feeling tired or weak.
- Belly pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For healthcare professionals
Applies to morphine/naltrexone: oral capsule extended release.
General
The most common adverse events included constipation, nausea, and somnolence.[Ref]
Psychiatric
- Common (1% to 10%): Insomnia, anxiety, depression, restlessness, irritability
- Frequency not reported: Disorientation, abnormal thinking, mental status changes, confusional state, euphoric mood, hallucination, abnormal dreams, mood swings, nervousness[Ref]
Disorientation, abnormal thinking, mental status changes, confusional state, euphoric mood, hallucination, abnormal dreams, mood swings, and nervousness, were reported in less than 1% of patients.[Ref]
Nervous system
- Very common (10% or more): Somnolence (14%),
- Common (1% to 10%): Dizziness, headache, tremor
- Frequency not reported: Depressed level of consciousness, mental impairment, memory impairment, disturbance in attention stupor, paresthesia, abnormal coordination[Ref]
Depressed level of consciousness, mental impairment, memory impairment, disturbance in attention stupor, paresthesia, and abnormal coordination, were reported in less than 1% of patients.[Ref]
Gastrointestinal
- Very common (10% or more): Constipation (up to 31%), nausea (up to 22%)
- Common (1% to 10%): Vomiting, dry mouth, diarrhea, abdominal pain upper, abdominal pain, dyspepsia, flatulence, stomach discomfort
- Frequency not reported: Abdominal distension, pancreatitis, fecaloma, abdominal tenderness[Ref]
Abdominal distension, pancreatitis, fecaloma, abdominal tenderness, were reported in less than 1% of patients.[Ref]
Cardiovascular
- Common (1% to 10%): Flushing, peripheral edema
- Frequency not reported: Orthostatic hypotension[Ref]
Orthostatic hypotension was reported in less than 1% of patients.[Ref]
Respiratory
- Frequency not reported: Dyspnea, rhinorrhea[Ref]
Dyspnea and rhinorrhea were reported in less than 1% of patients.[Ref]
Respiratory
Hepatic
- Frequency not reported: Cholecystitis, ALT and AST increases[Ref]
Cholecystitis, ALT and AST increases were reported in less than 1% of patients.[Ref]
Metabolic
- Common (1% to 10%): Anorexia, decreased appetite[Ref]
Dermatologic
- Common (1% to 10%): Hyperhidrosis, pruritus
- Frequency not reported: Rash, piloerection, cold sweat, night sweats[Ref]
Rash, piloerection, cold sweat, and night sweats were reported in less than 1% of patients.[Ref]
Musculoskeletal
- Common (1% to 10%): Muscle spasms, arthralgia
- Frequency not reported: Myalgia, muscle weakness[Ref]
Myalgia and muscle weakness were reported in less than 1% of patients.[Ref]
Ocular
- Frequency not reported: Blurred vision[Ref]
Blurred vision was reported in less than 1% of patients.[Ref]
Genitourinary
- Frequency not reported: Urinary retention, dysuria[Ref]
Urinary retention and dysuria were reported in less than 1% of patients.[Ref]
Endocrine
- Frequency not reported: Erectile dysfunction[Ref]
Erectile dysfunction was reported in less than 1% of patients[Ref]
Hypersensitivity
- Frequency not reported: Anaphylaxis[Ref]
Anaphylaxis has been reported with ingredients contained in this product.[Ref]
Other
- Common (1% to 10%): Fatigue, chills, lethargy
- Frequency not reported: Malaise, asthenia, drug withdrawal syndrome[Ref]
Malaise, asthenia, and drug withdrawal syndrome, were reported in less than 1% of patients.[Ref]
References
1. (2009) "Product Information. Embeda (morphine-naltrexone)." King Pharmaceuticals Inc
More about Embeda (morphine / naltrexone)
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- Reviews (47)
- Drug images
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: narcotic analgesic combinations
Patient resources
Professional resources
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Further information
Embeda side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.