Cocaine Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 22, 2025.

Applies to cocaine topical: topical solution.

Important warnings This medicine can cause some serious health issues

Topical route (solution)

Not for injection or ophthalmic use.

Common side effects of cocaine topical

Some side effects of cocaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• loss of sense of taste or smell (after use in the nose or mouth)

Serious side effects of cocaine topical

Along with its needed effects, cocaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cocaine topical:

Less common or Rare

• Abdominal or stomach pain
• chills
• confusion
• dizziness or lightheadedness
• excitement, nervousness, restlessness, or any mood or mental changes
• fast or irregular heartbeat
• general feeling of discomfort or illness
• hallucinations or seeing, hearing, or feeling things that are not there
• headache (sudden)
• increased sweating
• nausea

For healthcare professionals

Applies to cocaine topical: compounding powder, topical solution.

General adverse events

In general, most side effects are probably due to the high plasma drug levels resulting from excessive and rapid absorption of cocaine topical.^[Ref]

Cardiovascular

Cardiovascular side effects have included vasoconstriction, bradycardia associated with small doses, and increased heart rate associated with moderate doses.^[Ref]

Respiratory

Respiratory side effects have included fatal respiratory failure secondary to depression of the central nervous system.^[Ref]

Ocular

Ocular side effects have included mydriasis. Sloughing of the corneal epithelium, clouding, pitting, and corneal ulceration have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included vomiting.^[Ref]

Nervous system

Nervous system side effects have included nervousness, restlessness, excitement, tremors, and seizures (tonic-clonic).^[Ref]

Further information

Cocaine topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer