Cobenfy Side Effects

Generic name: trospium / xanomeline

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Note: This document provides detailed information about Cobenfy Side Effects associated with trospium / xanomeline. Some dosage forms listed on this page may not apply specifically to the brand name Cobenfy.

Applies to trospium / xanomeline: oral capsule.

Important warnings This medicine can cause some serious health issues

Use only as directed.

Tell your doctor if you use other medicines or have other medical conditions or allergies.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• racing or pounding heartbeats;

• heartburn, bloating;

• upset stomach or burning, upper stomach pain that may spread to your back;

• nausea, vomiting;

• stomach pain, constipation;

• confusion, sleep problems (insomnia), hallucinations (seeing or hearing things that are not real);

• fever, pain in your side or lower back, painful or difficult urination, increased urination, blood or pus in your urine;

• blurred vision, eye pain or redness, severe headache, seeing halos around lights; or

• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your doctor may need to adjust the dose or permanently discontinued your treatment with trospium and xanomeline if you have certain side effects.

Common side effects may include:

• a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion;

• upset stomach, constipation, or diarrhea;

• stomach pain or burning;

• nausea, vomiting;

• high blood pressure; or

• dizziness, fast heart rate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to trospium / xanomeline: oral capsule.

General adverse events

The most common adverse reactions were nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, and gastroesophageal reflux disease.^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (11%)
• Common (1% to 10%): Tachycardia/increased heart rate, orthostatic hypotension
• Postmarketing reports: Chest pain, hypertensive crisis, palpitations, supraventricular tachycardia, syncope

Dermatologic

• Postmarketing reports: Rash, angioedema, Stevens-Johnson syndrome

Gastrointestinal

• Very common (10% or more): Nausea (19%), dyspepsia/esophageal discomfort (18%), constipation (17%), vomiting (15%)
• Common (1% to 10%): Abdominal pain, diarrhea, gastroesophageal reflux disease, dry mouth, salivary hypersecretion
• Postmarketing reports: Gastritis

Genitourinary

• Common (1% to 10%): Urinary retention

Hepatic

• Common (1% to 10%): Elevated liver enzymes
• Frequency not reported: Biliary obstruction

Hypersensitivity

• Postmarketing reports: Anaphylactic reaction (including angioedema of the face, lips, tongue, and/or larynx)

Musculoskeletal

• Postmarketing reports: Rhabdomyolysis

Nervous system

• Common (1% to 10%): Dizziness, somnolence, extrapyramidal symptoms (non-akathisia)
• Frequency not reported: Anticholinergic central nervous system effects
• Postmarketing reports: Confusion, delirium, dizziness, hallucinations

Ocular

• Common (1% to 10%): Blurred vision
• Postmarketing reports: Abnormal vision

Respiratory

• Common (1% to 10%): Cough/productive cough

Further information

Cobenfy side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer