Cobenfy Dosage

Generic name: xanomeline 50mg, trospium chloride 20mg
Dosage form: capsule, coated pellets
Drug class: Psychotherapeutic combinations

Medically reviewed by Drugs.com. Last updated on Sep 30, 2024.

Recommended Testing and Monitoring Prior to Initiation and During Treatment with COBENFY

•: Assess liver enzymes and bilirubin prior to initiating COBENFY and as clinically indicated during treatment.
•: Assess heart rate at baseline and as clinically indicated during treatment.

Recommended Dosage and Administration

The recommended dosage of COBENFY is as follows:

•: The recommended starting dosage is one 50 mg/20 mg capsule (contains 50 mg of xanomeline and 20 mg of trospium chloride) orally twice daily for at least two days.
•: Increase the dosage to one 100 mg/20 mg capsule (contains 100 mg of xanomeline and 20 mg of trospium chloride) orally twice daily for at least five days.
•: The dosage may be increased to one 125 mg/30 mg capsule (contains 125 mg of xanomeline and 30 mg of trospium chloride) orally twice daily based on patient tolerability and response.
•: Maximum recommended dosage is 125 mg/30 mg orally twice daily.

Administer COBENFY orally at least one hour before a meal or at least two hours after a meal. Do not open the capsules.

Dosage Recommendations in Geriatric Patients

The recommended starting dosage of COBENFY in geriatric patients is one 50 mg/20 mg capsule orally twice daily. Consider a slower titration for geriatric patients. The maximum recommended dosage in geriatric patients is one 100 mg/20 mg capsule twice daily.