CellCept Side Effects

Generic name: mycophenolate mofetil

Medically reviewed by Drugs.com. Last updated on Nov 6, 2024.

Note: This document provides detailed information about CellCept Side Effects associated with mycophenolate mofetil. Some dosage forms listed on this page may not apply specifically to the brand name CellCept.

Applies to mycophenolate mofetil: oral capsule, oral powder for suspension, oral tablet.

Other dosage forms:

• intravenous powder for solution

Important warnings This medicine can cause some serious health issues

Oral route (capsule; tablet; powder for suspension)

Embryofetal Toxicity, Malignancies and Serious Infections. Use during pregnancy is associated with increased risks of first trimester pregnancy loss and congenital malformations.

Avoid if safer treatment options are available.

Females of reproductive potential must be counseled regarding pregnancy prevention and planning.Increased risk of development of lymphoma and other malignancies, particularly of the skin.Increased susceptibility to infections, including opportunistic infections and severe infections with fatal outcomes.

Serious side effects of CellCept

Along with its needed effects, mycophenolate mofetil (the active ingredient contained in CellCept) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mycophenolate mofetil:

More common side effects

• black, tarry stools
• bladder pain
• bleeding gums
• bloating or swelling of the face, arms, hands, lower legs, or feet
• blood in the urine or stools
• bloody or cloudy urine
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain or tightness
• confusion
• cough or hoarseness
• decreased urine
• difficult or labored breathing
• difficult, burning, or painful urination
• difficulty in moving
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• dry mouth
• fainting
• fast, slow, pounding, or irregular heartbeat or pulse
• fever or chills
• flushed, dry skin
• frequent urge to urinate
• fruit-like breath odor
• headache
• heartburn
• increased hunger
• increased thirst
• increased urination
• irregular heartbeats
• irregular pulse
• irritability
• lightheadedness
• loss of appetite
• loss of strength or energy
• lower back or side pain
• muscle cramps in the hands, arms, feet, legs, or face
• muscle pain, stiffness, cramps, or weakness
• muscle spasms (tetany) or twitching
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• pain in the joints
• painful or difficult urination
• pale skin
• pinpoint red spots on the skin
• pounding in the ears
• rapid weight gain
• rapid, shallow breathing
• seizures
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach cramps, pain, and bloating
• sweating
• swollen glands
• tingling of the hands or feet
• trembling
• tremor
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss
• weakness or heaviness of the legs

Incidence not known

• back pain
• bloody, black, tarry stools
• constipation
• coughing or spitting up blood
• darkened urine
• general feeling of illness
• indigestion
• night sweats
• pain
• pains in the stomach, side, or abdomen, possibly radiating to the back
• severe headache
• sudden high fever or low-grade fever for months
• tenderness
• watery or bloody diarrhea
• yellow eyes or skin

Other side effects of CellCept

Some side effects of mycophenolate mofetil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• acid or sour stomach
• belching
• fear
• heartburn
• lack or loss of strength
• rash
• trouble sleeping
• weight loss

For healthcare professionals

Applies to mycophenolate mofetil: intravenous powder for injection, oral capsule, oral powder for reconstitution, oral tablet.

Gastrointestinal adverse events

• Very common (10% or more): Diarrhea (36%), nausea (20%), vomiting (13%), abdominal pain
• Common (1% to 10%): GI infection, gastroenteritis
• Rare (less than 0.1%): Gingival hyperplasia, colitis including cytomegalovirus colitis, pancreatitis intestinal villous atrophy
• Frequency not reported: Ischaemic colitis^[Ref]

Hematologic

• Very common (10% or more): Leukopenia (11% to 35%), anemia (35%)
• Common (1% to 10%): Blood creatinine increased, blood lactate dehydrogenase increased, blood urea increased, blood alkaline phosphatase increased, thrombocytopenia, neutropenia
• Very rare (less than 0.01%): Deep venous thrombosis
• Postmarketing reports: Pure red cell aplasia (PRCA), abnormal neutrophil morphology, including the acquired Pelger-Huet anomaly, bone marrow failure, lymphocele^[Ref]

Immunologic

• Very common (10% or more): Sepsis (primarily cytomegalovirus viremia) (20%), gastrointestinal candidiasis, urinary tract infection, herpes simplex, herpes zoster
• Common (1% to 10%): Pneumonia, influenza, respiratory tract infection, respiratory moniliasis, gastrointestinal infection, candidiasis, gastroenteritis, infection, bronchitis, pharyngitis, sinusitis, fungal skin infection, skin candida, vaginal candidiasis
• Postmarketing reports: Hypogammaglobulinemia, hypersensitivity, and serious life-threatening infections including meningitis, endocarditis, tuberculosis, atypical mycobacterial infection^[Ref]

Oncologic

• Common (1% to 10%): Lymphoma, lymphoproliferative disease, non-melanoma skin carcinoma
• Uncommon (0.1% to 1%): Post-transplant lymphoproliferative disease (pseudolymphoma)^[Ref]

Renal

• Very common (10% or more): Hematuria (13%), kidney tubular necrosis (up to 10%)
• Common (1% to 10%): Renal impairment
• Frequency not reported: BK virus-associated nephropathy^[Ref]

Metabolic

• Very common (10% or more): Edema (12% to 28%), hyperphosphatemia (13%), hypokalemia (10%), hyperglycaemia (10%)
• Common (1% to 10%): Weight loss, hyperkalemia^[Ref]

Respiratory

• Very common (10% or more): Respiratory tract infection (23%), dyspnea (16%), increased cough (16%)
• Common (1% to 10%): Pneumonia, respiratory moniliasis, bronchitis, pharyngitis, sinusitis, rhinitis, pleural effusion
• Postmarketing reports: Bronchiectasis, interstitial lung disease, fatal pulmonary fibrosis^[Ref]

Dermatologic

• Common (1% to 10%): Fungal skin infection, skin hypertrophy, rash, acne, alopecia
• Very rare (less than 0.01%): Dyshidrotic eczema, papulosquamous psoriatic-like skin eruption^[Ref]

Other

• Common (1% to 10%): Edema, pyrexia, chills, pain, malaise, asthenia
• Frequency not reported: Congenital malformations, increased incidence of first trimester pregnancy loss^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia
• Very rare (less than 0.01%): Myopathy^[Ref]

Hepatic

• Common (1% to 10%): Hepatitis, jaundice, hyperbilirubinemia, hepatic enzyme increased
• Very rare (less than 0.01%): Sodium-induced hepatotoxicity^[Ref]

Cardiovascular

• Common (1% to 10%): Tachycardia, hypotension, hypertension, vasodilatation
• Postmarketing reports: Endocarditis, venous thrombosis^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection (up to 45%), vaginal candidiasis^[Ref]

Hypersensitivity

• Postmarketing reports: Angioneurotic edema, anaphylactic reaction^[Ref]

Further information

CellCept side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer