Advil Multi-Symptom Cold and Flu: Package Insert / Prescribing Info
Package insert / product label
Generic name: chlorpheniramine maleate, ibuprofen and phenylephrine hydrochloride
Dosage form: tablet, coated
Drug class: Upper respiratory combinations
Medically reviewed by Drugs.com. Last updated on Apr 14, 2025.
Active ingredients (in each tablet)
Chlorpheniramine maleate 4 mg
Ibuprofen 200 mg (NSAID)*
Phenylephrine HCl 10 mg
*nonsteroidal anti-inflammatory drug
Uses
- •
- temporarily relieves these symptoms associated with the common cold or flu:
- o
- headache
- o
- fever
- o
- minor body aches and pains
- o
- nasal congestion
- o
- runny nose
- o
- sinus pressure
- o
- sneezing
- •
- reduces swelling of the nasal passages
- •
- temporarily restores freer breathing through the nose
Warnings
Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
- •
- hives
- •
- facial swelling
- •
- asthma (wheezing)
- •
- shock
- •
- skin reddening
- •
- rash
- •
- blisters
If an allergic reaction occurs, stop use and seek medical help right away.
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
- •
- are age 60 or older
- •
- have had stomach ulcers or bleeding problems
- •
- take a blood thinning (anticoagulant) or steroid drug
- •
- take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others]
- •
- have 3 or more alcoholic drinks every day while using this product
- •
- take more or for a longer time than directed
Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use
- •
- in children under 12 years of age
- •
- if you have ever had an allergic reaction to any other pain reliever/fever reducer
- •
- right before or after heart surgery
- •
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
- •
- you have a breathing problem such as emphysema or chronic bronchitis
- •
- stomach bleeding warning applies to you
- •
- you have problems or serious side effects from taking pain relievers or fever reducers
- •
- you have a history of stomach problems, such as heartburn
- •
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, have trouble urinating due to an enlarged prostate gland, or had a stroke
- •
- you are taking a diuretic
Ask a doctor or pharmacist before use if you are
- •
- under a doctor's care for any serious condition
- •
- taking sedatives or tranquilizers
- •
- taking any other product that contains phenylephrine, chlorpheniramine or any other nasal decongestant or antihistamine
- •
- taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin
- •
- taking any other drug
When using this product
- •
- take with food or milk if stomach upset occurs
- •
- avoid alcoholic drinks
- •
- be careful when driving a motor vehicle or operating machinery
- •
- drowsiness may occur
- •
- alcohol, sedatives, and tranquilizers may increase drowsiness
- •
- may cause excitability especially in children
Stop use and ask a doctor if
- •
- you experience any of the following signs of stomach bleeding:
- o
- feel faint
- o
- vomit blood
- o
- have bloody or black stools
- o
- have stomach pain that does not get better
- •
- you have symptoms of heart problems or stroke:
- o
- chest pain
- o
- trouble breathing
- o
- weakness in one part or side of body
- o
- slurred speech
- o
- leg swelling
- •
- pain gets worse or lasts more than 7 days
- •
- fever gets worse or lasts more than 3 days
- •
- nasal congestion lasts for more than 7 days
- •
- redness or swelling is present in the painful area
- •
- you get nervous, dizzy, or sleepless
- •
- symptoms continue or get worse
- •
- any new symptoms appear
Directions
- •
- do not take more than directed
- •
- adults and children 12 years of age and over:
- o
- take 1 tablet every 4 hours while symptoms persist
- o
- do not take more than 6 tablets in any 24-hour period, unless directed by a doctor
- •
- children under 12 years of age: do not use
Other information
- •
- read all warnings and directions before use. Keep carton.
- •
- store at 20-25°C (68-77°F)
- •
- avoid excessive heat above 40°C (104°F)
Inactive ingredients
acesulfame potassium, artificial flavors, carnauba wax, colloidal silicon dioxide, corn starch, croscarmellose sodium, glycerin, glyceryl dibehenate, hypromellose, lactic acid, lecithin, maltodextrin, medium-chain triglycerides, microcrystalline cellulose, pharmaceutical ink, polydextrose, polyvinyl alcohol, pregelatinized starch, propyl gallate, silicon dioxide, sucralose, synthetic iron oxide, talc, titanium dioxide, triacetin, xanthan gum
Additional Information
READ AND KEEP CARTON FOR COMPLETE
WARNINGS AND INFORMATION
Product inside sealed in plastic blister with foil backing.
Do Not Use if plastic blister or foil barrier is broken.
Distributed by: GSK Consumer Healthcare, Warren, NJ 07059
For most recent product information,
visit www.advil.com
Trademarks owned or licensed by GSK ©2021 GSK or licensor
PRINCIPAL DISPLAY PANEL
Advil
MULTI-SYMPTOM
COLD & FLU
Ibuprofen 200 mg Pain Reliever/Fever Reducer (NSAID)
Phenylephrine HCl 10 mg Nasal Decongestant
Chlorpheniramine Maleate 4 mg Antihistamine
- •
- Headache
- •
- Fever
- •
- Body Aches
- •
- Sinus Pressure
- •
- Nasal Congestion
- •
- Runny Nose
- •
- Sneezing
- •
- Nasal Swelling
ONE
TABLET
DOSE!
30 Coated Tablets
000065883 Carton
| ADVIL MULTI-SYMPTOM COLD AND FLU
chlorpheniramine maleate, ibuprofen, phenylephrine hcl tablet, coated |
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| Labeler - Haleon US Holdings LLC (079944263) |
| Establishment | |||
| Name | Address | ID/FEI | Business Operations |
|---|---|---|---|
| PF Consumer Healthcare B.V. (Puerto Rico Operations) LLC | 118346012 | ANALYSIS(0573-0190) , LABEL(0573-0190) , MANUFACTURE(0573-0190) , PACK(0573-0190) | |
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