Study Looks at Impact of Hypothyroidism, Hypothyroxinemia in Pregnancy
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Aug. 21, 2024 -- For women with subclinical hypothyroidism (SH) or hypothyroxinemia (HT) diagnosed during the first half of pregnancy, SH is associated with higher rates of overt hypothyroidism or thyroid replacement therapy within five years of delivery, according to a study published online July 31 in Thyroid.
Michael W. Varner, M.D., from the University of Utah Health Sciences Center in Salt Lake City, and colleagues conducted a secondary analysis of two multicenter treatment trials for SH or HT diagnosed between 8 and 20 weeks of gestation, focusing on individuals randomly assigned to the placebo groups.
The researchers found that one- and five-year follow-up data were available for 307 of 338 participants with SH and 229 of 261 with HT. Compared to those with HT, participants with SH more often had subsequent hypothyroidism at years 1 (13.4 versus 3.1 percent) and 5 (15.6 versus 2.6 percent). This progression was seen more often among those with thyrotropin values >10 mIU/mL. Among individuals with SH, a baseline thyroid peroxidase (TPO) level >50 IU/mL versus ≤ 50 IU/mL was associated with higher rates of hypothyroidism at years 1 and 5 (odds ratios, 5.3 and 5.4, respectively). Among individuals with HT, there were no differences seen in overt hypothyroidism at one year, while more participants with TPO levels >50 IU/mL developed hypothyroidism by year 5 (odds ratio, 13.4).
"Our data lend further evidence to the postpartum time period as a time when autoimmune diseases, in this case, hypothyroidism, are more likely to be present," Varner said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
![](/img/logo/vendor/healthday-logo.png)
© 2024 HealthDay. All rights reserved.
Posted August 2024
Read this next
Smoking Before or During Pregnancy Tied to Severe Neonatal Morbidity
FRIDAY, Aug. 23, 2024 -- Maternal cigarette smoking before or during pregnancy increases the risk for severe neonatal morbidity (SNM), according to a study published online Aug...
Inflammation in Childhood Linked to Onset of Mental Health Disorders
FRIDAY, Aug. 23, 2024 -- Low-grade systemic inflammation across childhood and adolescence is associated with the subsequent onset of mental health disorders, according to a study...
Two-Thirds of COPD Hospitalized Patients Misuse Inhalers
FRIDAY, Aug. 23, 2024 -- Among patients hospitalized with a diagnosis of chronic obstructive pulmonary disorder (COPD), two-thirds of inhalers assessed at admission are misused...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.