Ekterly

Pronunciation: ek-TURR-lee
Generic name: sebetralstat
Dosage form: tablet (300mg)

Medically reviewed by Melisa Puckey, BPharm. Last updated on Jul 10, 2025.

What is Ekterly?

Ekterly is a prescription medication used to treat acute attacks of hereditary angioedema (HAE) in people 12 years of age and older. Ekterly tablets are taken as early as possible, wherever they are, to treat painful, debilitating, and sometimes life-threatening HAE attacks. 

Ekterly is available as an oral tablet, which is an advantage over other treatments that require intravenous or subcutaneous administration and may need to be administered in a healthcare facility.

Ekterly (sebetralstat) is a novel plasma kallikrein inhibitor. 

Ekterly works by blocking kallikrein, an enzyme that plays a crucial role in dilating blood vessels and increasing fluid leaking from capillaries. Blocking kallikrein reduces levels of bradykinin, the peptide that causes swelling during HAE attacks.

Ekterly side effects

The most common Ekterly side effect is headache, which affects 3% of patients.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088

Related/similar drugs

Before taking this medicine

Tell your healthcare provider about all of your medical conditions, including if you are: 

• Pregnant or planning to become pregnant, as it is not known if this medicine can harm your unborn baby. 

• Breastfeeding or planning to breastfeed, as it is not known if this medicine passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while taking this medicine.

• Have liver problems.

How should I take Ekterly?

Usual Ekterly dose

Ekterly tablet strength: 300mg. 

Take 2 tablets (600mg) by mouth at the earliest sign of an acute attack of hereditary angioedema. 

If you do not feel better or if your symptoms worsen or come back, take another 2 tablets (600mg) at least 3 hours after the first dose. 

Dose modifications

If you take certain medicines or if you have liver problems, your healthcare provider may change your dose to 1 tablet (300mg), by mouth, at the earliest sign of an acute attack of hereditary angioedema. If you do not feel better or if your symptoms worsen or come back, take another 1 tablet (300mg) at least 3 hours after the first dose. 

Take Ekterly exactly as your healthcare provider tells you to take it.

What happens if I overdose?

If you take too much of this medicine call your healthcare provider or Poison Help line at 1-800-222 1222 or go to the nearest hospital emergency room right away. 

Interactions

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Ekterly with certain other medicines can cause side effects or affect how well Ekterly or the other medicines work. Ekterly has a drug interaction with moderate and strong CYP3A4 Inhibitors, and moderate or strong CYP3A4 inducers. You may not be able to take Ekterly with these medications, or your dose may need to be reduced.

It is important to tell your healthcare provider if you take any of the following, as their use with Ekterly is not recommended: 

• Itraconazole
• Phenytoin
• efavirenz 

Many other drugs may interact with this medicine, and not all possible interactions are listed in this document. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine. 

Ekterly Package Insert 

Review the Ekterly Package Insert (Ekterly) for more detailed information about this medicine. The Ekterly Package Insert contains more comprehensive information on Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies, Drug Interaction, and more. Discuss any medical questions you have with your doctor or other health care provider. This is not all the information you need to know about this medicine for safe and effective use, and it does not take the place of talking to your doctor about your treatment.

The Package Insert is sometimes called Prescribing Information (PI) or the FDA label

Storage 

Store at room temperature between 68°F to 77°F (20°C to 25°C).

Ingredients

Active ingredient: sebetralstat

Inactive ingredients: croscarmellose sodium, glycerol mono and dicaprylocaprate, guar gum/guar galactomannan, hypromellose, iron oxide black, iron oxide yellow, macrogol polyvinyl alcohol graft copolymer, magnesium stearate, maltodextrin, medium chain triglycerides, microcrystalline cellulose, polyvinyl alcohol, povidone, talc, titanium dioxide.

Company 

Distributed by KalVista Pharmaceuticals, Inc. 55 Cambridge Parkway, Suite 901E, Cambridge, MA 02142

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer