Risk for Miscarriage Increased With Benzodiazepine Use in Pregnancy
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Dec. 27, 2023 -- After accounting for measurable confounders, the risk for miscarriage is increased in association with benzodiazepine use during pregnancy, according to a study published online Dec. 27 in JAMA Psychiatry.
Lin-Chieh Meng, from the National Taiwan University in Taipei, and colleagues quantified the risk for miscarriage associated with benzodiazepine use during pregnancy in a nationwide, population-based case-time-control study. Pregnancies resulting in miscarriage between 2004 and 2018 were included in the case group and matched in a 1:1 ratio with exposure time-trend control individuals using disease risk score. The study included 3,067,122 pregnancies among 1,957,601 women; 4.4 percent of these pregnancies resulted in miscarriage.
The researchers found that the risk for miscarriage was increased in association with use of benzodiazepines during pregnancy (odds ratio, 1.69); across multiple sensitivity analyses considering different time windows and accounting for misclassification, the results were consistent. An increased risk for miscarriage was seen in association with commonly used benzodiazepines, ranging from case-time-control odds ratios of 1.39 to 2.52 for alprazolam and fludiazepam, respectively.
"These findings suggest that caution is warranted when using benzodiazepines during early pregnancy," the authors write. "The findings of this study also provide evidence to guide clinicians in making informed decisions regarding the treatment of psychiatric and sleep disorders in pregnant women."
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted December 2023
Read this next
Soy Consumption in Children Tied to Better Thinking, Attention
TUESDAY, July 16, 2024 -- School-aged children who consume more soy foods may have improved thinking and attention, according to a study presented during NUTRITION 2024, the...
Total Dietary Quality Score Improved for U.S. Children During 2005 to 2020
MONDAY, July 15, 2024 -- Total dietary scores improved for U.S. children during 2005 to 2020, with increases for all diet adequacy components, apart from dairy, according to a...
Transcatheter PDA Closure Increasingly Used for Very Low Birth-Weight Infants
MONDAY, July 15, 2024 -- For very low birth-weight (VLBW) infants, transcatheter closure of the patent ductus arteriosus (PDA) is increasingly used, with selected short-term...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.