Metabolic Surgery Is Renoprotective in Patients With Obesity, CKD
By Elana Gotkine HealthDay Reporter
FRIDAY, Sept. 27, 2024 -- For patients with obesity, type 2 diabetes, and estimated glomerular filtration rate (eGFR) 20 to 60 mL/min/1.73 m2, metabolic surgery is associated with a lower risk for progression of kidney impairment compared with glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment, according to a study published in the September issue of the Annals of Surgery.
Ali Aminian, M.D., from the Cleveland Clinic, and colleagues examined the renoprotective effects of metabolic surgery in patients with established chronic kidney disease (CKD). Patients with obesity, type 2 diabetes, and eGFR 20 to 60 mL/min/1.73 m2 who underwent metabolic surgery were compared to nonsurgical patients who received GLP-1RA treatment. The analyses included 425 patients: 183 in the metabolic surgery group and 242 in the GLP-1RA group, with a median follow-up of 5.8 years.
The researchers found that the cumulative incidence of the primary end point of CKD progression at eight years was 21.7 and 45.1 percent in the surgical group and nonsurgical group, respectively, with an adjusted hazard ratio of 0.40. At eight years, the cumulative incidence of the secondary end point of incident kidney failure or all-cause mortality was 24.0 and 43.8 percent in the surgical and nonsurgical groups, respectively (adjusted hazard ratio, 0.56).
"Metabolic surgery should be considered as a therapeutic option for patients with CKD and obesity," the authors write.
Several authors disclosed ties to the pharmaceutical and medical technology industries.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted September 2024
Read this next
ENDO: Guidelines Developed for Pregnancy Care in Preexisting Diabetes
FRIDAY, July 18, 2025 -- In a joint clinical practice guideline issued by the Endocrine Society and European Society of Endocrinology, recommendations are presented for pregnancy...
Long-Term Obesity Linked to Expression of Aging Biomarkers
THURSDAY, July 17, 2025 -- Long-term obesity is associated with the expression of biomarkers denoting antagonistic and integrative aging hallmarks in adults aged 28 to 31 years...
ENDO: Older Age, Female Sex Tied to Greater Muscle Loss With Semaglutide
THURSDAY, July 17, 2025 -- Older age and female sex may be associated with greater muscle loss in adults with obesity prescribed semaglutide, and greater muscle loss is...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.