Causal Relationship Seen for RA and Adverse Pregnancy Outcomes
By Lori Solomon HealthDay Reporter
MONDAY, Aug. 12, 2024 -- There is a positive causal association for rheumatoid arthritis and adverse pregnancy outcomes (APOs), according to a study published online July 31 in BMC Pregnancy & Childbirth.
Tongmin Chang, from the Cheeloo College of Medicine at Shandong University in Jinan, China, and colleagues explored the potential causal relationships between rheumatoid arthritis and APOs using a bidirectional two-sample Mendelian randomization (MR) analysis in European and Asian populations.
In the European population, the researchers observed a causal association between rheumatoid arthritis and gestational hypertension (odds ratio [OR], 1.04), preeclampsia (OR, 1.06), fetal growth restriction (OR, 1.08), and preterm delivery (OR, 1.04). There was no evidence that APOs had causal effects on rheumatoid arthritis in the reverse MR analysis. In an East Asian population, there was no association between rheumatoid arthritis and APOs. Furthermore, no heterogeneity or horizontal pleiotropy was detected.
"In conclusion, this study confirmed the causal relationship between rheumatoid arthritis and adverse pregnancy outcomes in the European population," the authors write. "It highlights the importance of more intensive prenatal care and early intervention among pregnant women with rheumatoid arthritis to prevent potential adverse obstetric outcomes. However, due to the limitations of the study, further research is warranted."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted August 2024
Read this next
Rheumatoid Arthritis Tied to Higher Risk for Lung Cancer
FRIDAY, Aug. 9, 2024 -- Rheumatoid arthritis (RA) is associated with a significantly increased risk for lung cancer, according to a study published online July 28...
Cognitive Impairment More Often Experienced by Patients With RA
WEDNESDAY, July 31, 2024 -- Patients with rheumatoid arthritis (RA) with moderate-to-high inflammation are more likely to experience cognitive impairment, according to a study...
Positive Causal Association Between Rheumatoid Arthritis, Bronchiectasis
WEDNESDAY, July 24, 2024 -- There is a causal association between genetically predicted rheumatoid arthritis (RA) and increased risk of bronchiectasis, according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.