Antibody-Positive Males Face Higher Risk for Type 1 Diabetes Progression
By Lori Solomon HealthDay Reporter
TUESDAY, Aug. 6, 2024 -- The risk for progression to type 1 diabetes (T1D) is significantly higher in antibody-positive males compared with females, with age differences in risk trajectories, according to a study scheduled to be presented at the annual meeting of the European Association for the Study of Diabetes, being held from Sept. 9 to 13 in Madrid.
Erin L. Templeman, from the University of Exeter in the United Kingdom, and colleagues assessed the risk and rate of progression for individuals at risk for T1D participating in the TrialNet Natural History study. The analysis included 235,765 relatives of people with T1D screened for autoantibody (AB) positivity.
The researchers found that the proportion of individuals who screened positive for ABs was higher in males (females: 0.05; males: 0.054). Of those screening positive, males were more likely to screen positive for multiple ABs (females: 0.018; males: 0.026). Additionally, the absolute five-year risk for progression to T1D was significantly higher among males who were single AB-positive (14 percent for females versus 21 percent for males). A similar risk was seen for males and females presenting with stage 1 (females: 38 percent; males: 38 percent) or stage 2 (females: 57 percent; males: 59 percent). For females, a large decrease in five-year T1D risk was seen when screened and autoantibody-positive before age 10 years versus after age 10 years. However, there was a steady decline in five-year T1D risk among males as age at screening increased.
"The change in risk at around the age of 10 raises the hypothesis that puberty-related hormones may play a role," the authors said in a news release.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
Consistent Physical Activity Linked to Reduced All-Cause, CVD Mortality
FRIDAY, July 11, 2025 -- Consistently and increasingly accumulated physical activity (PA) is associated with a reduced risk for all-cause and cardiovascular disease (CVD)...
Increased Liver Enzyme Levels Seen With Use of Cannabidiol in Adults
THURSDAY, July 10, 2025 -- Use of cannabidiol (CBD) within the range consumers are taking with unregulated CBD products is associated with increased liver enzyme levels, according...
Majority of Patients With Lyme Disease Do Not Follow Up With Clinician
THURSDAY, July 10, 2025 -- Only 34 percent of patients with erythema migrans >5 cm are positive for Lyme disease by a standard two-tier testing (STTT) algorithm, and of...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.