Tyrvaya (nasal)
Generic name: varenicline (nasal) [ var-EN-i-kleen- ]
Other brand names of varenicline (nasal) include Tyrvaya
Drug class: Cholinergic agonists
What is varenicline nasal?
Varenicline nasal (for the nose) is used in adults to treat symptoms of dry eye disease. Varenicline nasal works by increasing tear production in the eye after being sprayed into the nose.
Varenicline nasal may also be used for purposes not listed in this medication guide.
Varenicline nasal side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Common side effects of Tyrvaya may include:
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sneezing;
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cough; or
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nose or throat irritation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Warnings
Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.
Before taking this medicine
Tell your doctor if you have or ever had health problems or use other medications.
It is not known if varenicline nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using this medicine.
How should I use varenicline nasal?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Varenicline nasal is for use in the nose.
Do not shake the bottle.
Varenicline nasal is usually sprayed once in each nostril twice per day (about 12 hours apart).
Read and carefully follow any Instructions for Use provided with your medicine. Be sure you understand how to properly prepare your first dose. Talk to your doctor or pharmacist if you do not understand these instructions or have any questions.
To use the nasal spray:
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Before your first use, prime it with 7 sprays into the air, away from your face.
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Tilt your head back slightly without lying down and insert the tip of bottle into the nostril. Breathe in and spray the medicine into your nose. Use in your other nostril as directed.
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If the spray gets in your eyes or mouth or on your skin, rinse with water.
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Clean the nasal applicator after each use.
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Prime again whenever the inhaler has not been used in longer than 5 days.
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Do not use the second bottle until you are done with the first bottle. Each bottle has about 15 days of treatment.
Store at room temperature away from moisture and heat. Do not freeze. Once opened, throw away the medicine after 30 days.
What happens if I miss a dose?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using varenicline nasal?
Avoid priming varenicline nasal more than needed. Priming will reduce the amount of medicine left in the bottle.
What other drugs will affect varenicline nasal?
Other drugs may affect varenicline nasal, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Popular FAQ
How often can you use Tyrvaya?
Tyrvaya should be sprayed into each nostril twice a day (about every 12 hours) to treat the signs and symptoms of dry eye disease. Follow the special Instructions for Use included with your prescription to learn how to correctly spray Tyrvaya, or ask your healthcare provider.
How quickly does Tyrvaya work?
When used twice a day in each nostril, Tyrvaya nasal spray may start working as quickly as the first week to increase eye tear film production. In clinical studies, Tyrvaya increased tear production and relief of symptoms at 4 weeks, on average, in mild to severe dry eye disease.
Can you use Tyrvaya long term?
The recommended dose is one spray in each nostril twice daily (about every 12 hours). Only change your dose or stop treatment if directed by your doctor. Tyrvaya is a prescription nasal spray used to treat symptoms of dry eye disease.
What is the mechanism of action of Tyrvaya?
Tyrvaya works by activating a pathway in the nose that is responsible for your own natural tear production. It is thought to work as an agonist by binding to the nicotinic acetylcholine (nACh) receptor. This binding activates the trigeminal parasympathetic pathway in the nose to increase basal tear production. Continue reading
How long does a bottle of Tyrvaya last?
A bottle of Tyrvaya will last 15 days. This is because it contains 60 sprays and the recommended dose is ONE spray into BOTH nostrils Twice daily. This means you will use 4 sprays per day in total which will last 15 days. Each prescription of Tyrvaya comes with 2 glass nasal spray bottles which will last you 30 days in total. Continue reading
Does Tyrvaya reduce inflammation?
Tyrvaya does not reduce inflammation, it targets the trigeminal parasympathetic pathway which stimulates the lacrimal functional unit – an integrated system consisting of the lacrimal glands, surface of the eye, goblet glands and meibomian glands, and the nerves that connect them – to improve the quality and quantity of tear film produced. The trigeminal parasympathetic pathway is accessible through the nose, which is why Tyrvaya is produced as a nasal spray. This allows effective treatment of dry eye without the burning and stinging often associated with eye drops. Continue reading
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Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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