Suzetrigine

Generic name: suzetrigine
Brand name: Journavx
Dosage form: oral tablet (50 mg)
Drug class: Miscellaneous analgesics

Medically reviewed by Drugs.com on Feb 18, 2025. Written by Cerner Multum.

What is suzetrigine?

Suzetrigine is a non-narcotic pain medicine used to treat moderate to severe acute pain in adults.

Suzetrigine may also be used for purposes not listed in this medication guide.

Suzetrigine side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Less serious side effects may be more likely, or you may have none at all.

Common side effects of suzetrigine may include:

• itching;

• skin rash;

• muscle spasm; or

• abnormal lab tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Tell your doctor about all your other medicines. Some drugs should not be used with suzetrigine.

Before taking this medicine

Some drugs should not be used with suzetrigine. Your treatment plan may change if you also use certain other medicines for infections, seizures, birth control, high cholesterol, organ transplant rejection, prevention of nausea and vomiting, HIV, high blood pressure or heart problems.

Tell your doctor if you have or have ever had:

• liver disease.

It may be harder for you to get pregnant while you are using suzetrigine. Talk to your doctor if you plan to get pregnant.

Suzetrigine can make certain hormonal birth control with progestins, other than levonorgestrel or norethindrone, less effective. Use either additional barrier birth control or an alternative hormonal birth control while using this medicine and for at least 28 days after your last dose.

It is not known if suzetrigine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take suzetrigine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Never use suzetrigine in larger amounts, or for longer than prescribed. Use the medicine exactly as directed.

Swallow the tablet whole and do not crush, chew, or break it.

Read and carefully follow any instructions provided with your medicine. Be sure you understand how to take your medicine over the treatment course. Talk to your doctor or pharmacist if you do not understand these instructions or have any questions.

Take your first dose on an empty stomach, at least 1 hour before or 2 hours after a meal. You may drink clear liquids, such as water, apple juice, tea, or black coffee during this time.

After the first dose, suzetrigine is usually taken with or without food every 12 hours.

If you have liver problems or take certain other medicines, your treatment schedule may be different. Follow your doctor's instructions.

Store at room temperature away from moisture and heat.

Suzetrigine dosing information

Usual Adult Dose for Pain:

Initial dose: 100 mg orally once
Maintenance dose: 50 mg orally every 12 hours, with or without food

Duration of therapy: Should be used for the shortest duration, consistent with individual patient treatment goals

Comments:
-Administer maintenance dose 12 hours after the initial dose.
-Using this drug for the treatment of moderate to severe acute pain has not been studied beyond 14 days.

Use: For the treatment of moderate to severe acute pain

What happens if I miss a dose?

Since suzetrigine is used for pain, you are not likely to miss a dose. If you miss a dose, take it as soon as you remember. Follow your doctor's instructions about what to do for your next dose. Do not take two doses at one time.

If you missed more than 1 dose, have liver problems, or take certain other medicines, your dosing schedule may be different.

If you are unsure about what to do, call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking suzetrigine?

Grapefruit may interact with suzetrigine and cause side effects. Avoid consuming grapefruit products.

What other drugs will affect suzetrigine?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

When you start or stop taking suzetrigine, your doctor may need to adjust the doses of other medicines you use on a regular basis.

Many drugs can affect suzetrigine, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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