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Nicotine (nasal, inhalation)

Generic name: nicotine (nasal, inhalation) [ NIK-oh-teen ]
Brand names: Nicotrol Inhaler, Nicotrol NS
Dosage forms: inhalation device (10 mg), nasal spray (10 mg/mL)
Drug class: Smoking cessation agents

Medically reviewed by Drugs.com on Sep 2, 2024. Written by Cerner Multum.

What is nicotine?

Nicotine is the primary ingredient in tobacco products.

Nicotine nasal spray and inhalation are medical products used to help you stop smoking and help reduce nicotine withdrawal symptoms as you quit smoking.

Nicotine nasal or inhalation may also be used for purposes not listed in this medication guide.

Nicotine nasal or inhalation side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

nicotine may cause serious side effects. Stop using nicotine and call your doctor at once if you have:

Use nicotine nasal regularly during the first week to help you adjust to some of the common side effects, such as irritation in your nose or throat.

Common side effects of nicotine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use nicotine if you are allergic to nicotine or menthol.

Tell your doctor if you have ever had:

Nicotine can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Smoking cigarettes during pregnancy can cause low birth weight, miscarriage, or stillbirth. Using a nicotine replacement product during pregnancy or while breast-feeding may be safer than smoking. However, you should try to stop smoking without using a nicotine replacement product if you are pregnant or breastfeeding. Talk with your doctor about the best way for you to stop smoking.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Do not give this medicine to a child or teenager without medical advice.

How should I use nicotine nasal or inhalation?

This medicine is only part of a complete program of treatment that may also include counseling, group support, and behavior changes. Your success will depend on your participation in all aspects of your smoking cessation program.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Tell your doctor if you feel an increased urge to use more of this medicine.

Start using nicotine nasal or inhalation on the same day you stop (quit) smoking or using tobacco products.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Nicotine nasal is generally used for up to 8 weeks, and then gradually reduced over the following 4 to 6 weeks. Nicotine inhalation is generally used for up to 12 weeks, and then gradually reduced over the following 12 weeks. Follow your doctor's instructions for tapering your dose.

Call your doctor if you are unable to stop smoking after using nicotine nasal for 4 weeks, or after using nicotine inhalation for 6 weeks. This medicine may be habit-forming if you use it for too long. Do not use this medicine for longer than 6 months without the advice of your doctor.

Nicotine nasal spray may not work as well if you have a cold or allergy symptoms and a runny nose.

Store at room temperature away from moisture, heat, and light. Protect nicotine inhalation from cold temperatures. Keep the nasal spray bottle tightly closed when not in use. Store inhaler cartridges away from open flame or high heat, such as in a car on a hot day.

Keep this medicine out of the reach of children or pets. Follow all printed instructions about how to safely throw away an empty nasal spray bottle or inhaler cartridge.

As you quit smoking, you may have nicotine withdrawal symptoms, such as: dizziness, drowsiness, trouble concentrating, mood changes (feeling restless, anxious, or irritable), headache, muscle pain, trouble sleeping, increased appetite, constipation, or weight gain.

What happens if I miss a dose?

Since nicotine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

Do not use the nasal spray more than 5 times per hour or 40 times in 24 hours. Do not use more than 16 nicotine inhaler cartridges per day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nicotine can be fatal.

Overdose symptoms may include headache, dizziness, vomiting, diarrhea, stomach pain, confusion, problems with hearing or vision, weakness, tremors, rapid heartbeats, pale skin, cold sweat, fainting, seizure (convulsions), or slow breathing (breathing may stop).

The amount of nicotine in a used or unused bottle or cartridge can cause serious harm to a child who accidentally sucks or chews on it. Seek emergency medical attention if this happens.

What should I avoid while using nicotine nasal or inhalation?

Avoid getting nicotine nasal in your mouth, eyes, ears, or on your skin or lips. If this occurs, rinse with water.

Ask a doctor before using any other nasal sprays, especially a decongestant spray that contains xylometazoline (such as Triaminic Decongestant).

What other drugs will affect nicotine?

When you start or stop using nicotine, your doctor may need to adjust the doses of any other medicines you take on a regular basis.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect nicotine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does nicotine interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Popular FAQ

How long does nicotine withdrawal last?

Nicotine withdrawal symptoms can last for several months, although they are typically at their worst during the first week of quitting, especially the first 3 to 5 days. Even though physical cravings tend to subside within a few weeks, the mental and emotional effects associated with nicotine withdrawal may last months, and you may need some help from your doctor to get through these, particularly if you have a history of anxiety or depression. Continue reading

How long does nicotine stay in your system?

Generally, it takes 1 to 3 days after you stop using tobacco for nicotine to clear your blood system and up to 10 days for cotinine (the major breakdown product of nicotine) to be gone. This is an estimate because people process nicotine differently depending on their genetics and it also depends on how much you inhale and how much nicotine is in the cigarette. Continue reading

More FAQ

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.