mResvia

Pronunciation: em-res’-vee-ah
Generic name: respiratory syncytial virus vaccine
Dosage form: prefilled syringe for intramuscular use
Drug class: Viral vaccines

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 5, 2024.

What is mResvia?

mResvia is an RSV vaccine that may be used to protect adults aged 60 years and older against lower respiratory tract disease (LRTD) caused by respiratory syncytial virus (RSV). It is given as a single injection, usually into the muscle of the upper arm.

• Vaccination with mResvia may not protect everybody who receives it.

mResvia is a modified RNA vaccine, and its mechanism of action involves encoding for a particular protein present on the RSV virus. When given, mResvia instructs your body to make a harmless piece of the RSV virus which your immune system recognizes as foreign and creates antibodies against it. These antibodies target the pre-F form of this RSV protein and can help your body fight the RSV infection.

mResvia does not contain RSV and cannot give you lower respiratory tract disease caused by RSV.

mResvia gained FDA approval on 31 May 2024. 

• mResvia was the third vaccine approved for RSV, and the only modified RNA vaccine.
• The other 2 RSV vaccines are Arexvy (approved for pregnant women and adults aged 60 and older) and Abrysvo (only approved for adults aged 60 and older).

mResvia side effects

The most common side effects of mResvia are:

• Injection site reactions, such as pain, underarm swelling or tenderness in the same arm of the injection, swelling (hardness), and redness
• Fatigue/tiredness
• Headache
• Muscle or joint pain
• Chills.

Other, less common side effects include nausea or vomiting, fever, hives, and facial paralysis.

Most side effects get better within 24 to 48 hours.

Serious side effects and warnings

mResvia may cause the following serious side effects.

There is a very small chance that mResvia could cause a severe allergic reaction. A severe allergic
reaction would usually occur within a few minutes to one hour after getting a dose of mResvia. For this
reason, your healthcare provider may ask you to stay for a short time at the place where you received
your vaccine. Signs of a severe allergic reaction may include:

• Trouble breathing
• Swelling of your face and throat
• A fast heartbeat
• A rash all over your body
• Dizziness and weakness.

Fainting may occur following the administration of vaccines, such as mResvia. Sit or lie down during the vaccination to avoid injury from fainting.

People who are immunocompromised, including those receiving immunosuppressive therapy, may have a diminished immune response to vaccines.

mResvia is for people aged 60 years and older. It should not be given to younger people or pregnant women.

These may not be all of the possible side effects of mResvia. Ask your healthcare provider about any side effects that concern you. You may report side effects to the Vaccine Adverse Event Reporting
System (VAERS) at 1-800-822-7967 or https://vaers.hhs.gov. 

Related/similar drugs

Before taking

Tell your healthcare provider about all of your medical conditions, including if you:

• have any allergies
• had a severe allergic reaction after receiving a previous dose of any other vaccine
• have a fever
• have a bleeding disorder or are on a blood thinner
• are immunocompromised or are on a medicine that affects your immune system
• have received any other RSV vaccine
• have ever fainted in association with an injection
• are under the age of 60.

mResvia is not approved for use during pregnancy.

Read the FDA-approved patient labeling information for recipients and caregivers before receiving mResvia. If you would like more information, talk to your healthcare provider, or visit mResvia.com or call 1-866-MODERNA (1-866-663-3762).

How is mResvia administered?

mResvia is given as an injection into the muscle, usually the deltoid muscle of the outer, upper arm.

• The dose is 0.5 mL.

Because of the small risk of an allergic reaction occurring, you may be asked to stay for a short time at the place where you received your vaccine and where appropriate medical treatment is available.

mResvia ingredients

Active: messenger ribonucleic acid (mRNA) that encodes for the RSV F glycoprotein

Inactive: lipids (SM-102, polyethylene glycol dimyristoyl glycerol [PEG2000-DMG], cholesterol, and 1,2- distearoyl-sn-glycero-3-phosphocholine [DSPC]), tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate trihydrate, sucrose, water

mResvia does not contain a preservative.

Who makes mResvia?

Moderna US, Inc. makes mResvia.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer