Does Vraylar (cariprazine) cause weight gain?

Vraylar (cariprazine), like other atypical antipsychotic drugs, can lead to metabolic changes that may result in weight gain. However, real-world clinical experience suggests that weight gain with Vraylar is less problematic compared to other antipsychotics.

How Much Weight Might I Gain on Vraylar?

Weight gain varies depending on the condition being treated. Clinical trials reported the following average weight changes:

Schizophrenia:

• 6 weeks: +2.2 lbs (1.0 kg) (placebo: +0.7 lbs (0.3 kg))
• 12 weeks: +2.6 lbs (1.2 kg)
• 24 weeks: +3.7 lbs (1.7 kg)
• 48 weeks: +5.5 lbs (2.5 kg)

Bipolar depression:

• 6–8 weeks: +1.2 lbs (0.5 kg) (placebo: -0.2 lbs (-0.1 kg))

Bipolar mania:

• 3 weeks: +1.1 lbs (0.5 kg) (placebo: +0.4 lbs (0.2 kg))

Major depressive disorder (as an add-on treatment):

• 26 weeks: +3.7 lbs (1.7 kg)
• Long-term trial: 19% experienced ≥7% weight increase, 5% experienced ≥7% weight loss

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How Does Vraylar Compare to Other Antipsychotics for Weight Gain?

An international panel of clinicians with real-world experience with Vraylar reported that weight gain is not a particularly problematic side effect of Vraylar. Additionally, fewer patients discontinued Vraylar due to weight gain compared to other similar medications.

How Should I Monitor Weight Gain While Taking Vraylar?

Patients taking Vraylar should monitor their weight regularly, including:

• Baseline measurement before starting treatment
• Ongoing weight checks during treatment to detect significant changes

If you experience unexpected weight gain, consult your healthcare provider for guidance on lifestyle adjustments or alternative treatment options.