Will Lybalvi trigger a false positive for opioids?

Yes, Lybalvi (olanzapine and samidorphan) can cause a false positive urine test result for opioids on certain tests used for detecting opioids. Specifically, urinary immunoassay methods are not reliable. The manufacturer suggests using an alternative test for opioids if you are taking Lybavli, such as chromatographic methods, instead.

Is Lybalvi an opioid?

No, Lybalvi is not an opioid. It contains olanzapine (an antipsychotic) and samidorphan (an opioid antagonist). Instead of activating opioid receptors, samidorphan blocks them.

How long does Lybalvi stay in your system?

For most people, it takes around 11 days for Lybalvi to fully leave your system. Lybalvi contains two active ingredients, olanzapine and samidorphan. The half-life of olanzapine is around 32-55 hours, while the half life of samidorphan is 7-11 hours. A half-life is a measure of how long it takes for half of the amount of medication in the blood to leave the body. Samidorphan has a shorter half-life than olanzapine, and is expected to be fully eliminated from the body within 2-3 days.

Can I take Lybalvi if I am taking an opioid?

No, you should not take Lybalvi if you are currently taking an opioid. This is because one of the active ingredients in Lybalvi, samidorphan, is an opioid antagonist. It can cause opioid withdrawal in people who are taking opioids.

If you are currently taking an opioid, it is recommended to wait 7 days after stopping short-acting opioids and 14 days after stopping long-acting opioids before starting Lybalvi.

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Is Lybalvi a controlled substance?

No, Lybalvi is not a controlled substance. It has not been shown to have a risk of abuse, addiction, or dependence.

Does Lybalvi cause opioid withdrawal?

Yes, Lybalvi can cause opioid withdrawal if you start it while taking an opioid. One of the components of Lybalvi, samidorphan, is an opioid antagonist. This means it blocks opioids from interacting with their receptors. When your body is not able to respond to your opioid medication so abruptly, it can experience serious withdrawal symptoms. This can sometimes even lead to hospitalization. For this reason, you should stop taking opioid medications before starting Lybavi.

Am I more likely to overdose on opioids if I take Lybalvi?

If you were previously taking opioids long-term while taking Lybalvi, you may be more sensitive to treatment with opioids when you stop taking Lybalvi. This can raise your risk of an opioid overdose. Work closely with your pain management specialist to carefully restart or adjust opioid treatment if you stop taking Lybalvi. It is likely you will need to take a lower dose than you were used to taking previously when you were taking Lybalvi.

This is not all the information you need to know about Lybalvi (olanzapine and samidorphan) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.