Does Lybalvi cause weight gain?
Weight gain is a possible side effect of Lybalvi (olanzapine and samidorphan). During a 4-week clinical trial, 19% of people taking Lybalvi reported weight gain compared to 3% of people taking a placebo (no active medication). In a 24-week study, 25% of people taking Lybalvi reported gaining weight.
How much weight will I gain while taking Lybalvi?
Not everyone will experience weight gain from taking Lybalvi. The amount of weight you may gain depends on factors such as your starting weight, diet, exercise habits, other medications, and how long you are taking Lybalvi.
During a 4-week study of adults with schizophrenia, people taking Lybalvi gained an average of 3 kg (6.6 lbs). This was compared to 2.4 kg (5.3 lbs) in people taking olanzapine and 0.2 kg (0.4 lbs) in people taking a placebo.
In a 24-week clinical trial, patients taking Lybalvi gained around 4.2% of their starting body weight. Around 18% of people taking Lybalvi saw a 10% increase or more in their body weight.
How can I prevent weight gain from Lybalvi?
It may not always be possible to prevent weight gain as a side effect of Lybalvi. However, there are some things you can do to help lower your risk and minimize the amount of weight you gain:
- Maintain a balanced diet while avoiding processed foods
- Be mindful of portion sizes when eating meals
- Keep up a regular exercise routine
If you notice you are gaining weight while taking Lybalvi, tell your healthcare provider.
This is not all the information you need to know about Lybalvi (olanzapine and samidorphan) for safe and effective use. Review the full Lybalvi (olanzapine and samidorphan) information, and discuss this information and any questions with your doctor or other health care provider.
References
Lybalvi [package insert]. Updated January 2024. Alkermes, Inc. Accessed September 23, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=32ffddd1-4e2b-45d9-9b36-bb730167ec80
Read next
Is obesity a major risk factor for Covid-19?
Obesity is a major risk factor for covid-19 and people who are obese are more likely than those who are not obese to contract Covid-19 at a younger age, develop severe Covid-19, require hospitalization, oxygen, mechanical ventilation, intubation, or admission into ICU, end up in hospital sooner, or die from Covid-19. Continue reading
Ozempic Side Effects to Watch For
The most common Ozempic side effects with Ozempic include stomach problems, like nausea, vomiting, diarrhea, stomach pain and constipation. These tend to be mild-to-moderate and usually clear up in a few weeks in most people. Low blood sugar (hypoglycemia) is also a common side effect (when used with certain other diabetes treatments) and it can be serious. Continue reading
Mounjaro vs Ozempic: How do they compare?
Mounjaro and Ozempic are prescription medicines used alongside diet and exercise to help control blood sugar (glucose) levels in adults with type 2 diabetes. Ozempic is also approved to lower the risk of a major cardiovascular event (like a heart attack or stroke) in patients with type 2 diabetes. Mounjaro has not yet received this indication, although studies are ongoing.
In a large, 2024 retrospective study in adults with overweight or obesity and treated for type 2 diabetes, Mounjaro led to at least a 5% weight loss within one year in 81.8% of adults compared to 66.5% of those using Ozempic. Continue reading
Related medical questions
- How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?
- Ozempic vs Wegovy: What's the difference between them?
- Why am I not losing weight on Mounjaro?
- Tirzepatide vs semaglutide: How do they compare?
- How long until I lose weight on Wegovy?
- Does Wellbutrin XL/SR cause weight gain or loss?
- What happens when you stop taking Ozempic?
- How does Ozempic (semaglutide) help with weight loss?
- Why does Lexapro cause weight gain?
- Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?
- Does Zoloft (sertraline) cause weight gain?
- Can you get tirzepatide from a compounding pharmacy?
- How does Mounjaro Work for Weight Loss?
- Is Mounjaro covered by insurance or Medicare?
- Will my insurance cover Ozempic?
- How does semaglutide work for weight loss?
- Does Prozac cause weight gain or loss?
- How long does it take for Zepbound to work?
- Why am I not losing weight on Ozempic?
- Why am I not losing weight on Saxenda?
- How much does semaglutide cost?
- How do you get Wegovy covered by insurance?
- Do you gain weight back after stopping Mounjaro?
- How does Ozempic affect blood pressure?
- How do Zepbound and Wegovy compare?
- Is Zepbound covered by insurance?
- How long can you stay on Ozempic?
- Does Jardiance cause weight loss?
- Does Cymbalta cause weight gain?
- How does taking Ozempic affect your face?
Drug information
- Lybalvi Information for Consumers
- Lybalvi prescribing info & package insert (for Health Professionals)
- Side Effects of Lybalvi (detailed)
Related support groups
- Lybalvi (1 questions, 3 members)
- Weight Loss (Obesity/Overweight) (767 questions, 1,492 members)
- Schizophrenia (96 questions, 324 members)
- Bipolar Disorder (495 questions, 3,179 members)