Mulpleta vs Doptelet - What's the difference?

The key differences between Mulpleta and Doptelet include indications, dosing, timing, tablet strength, and side effects. Mulpleta may be taken with or without food. Doptelet should always be taken with food.

Both Mulpleta (lusutrombopag) from Shionogi Inc. and Doptelet (avatrombopag) from Swedish Orphan Biovitrum AB (Sobi) are once-daily, orally administered, thrombopoietin (TPO) receptor agonists for the treatment of thrombocytopenia (low platelet count) in adults with chronic liver disease who are scheduled to undergo a procedure.

Mulpleta and Doptelet help to reduce the risk of bleeding and platelet transfusions.

Indications

Doptelet has an additional indication (use). It can also be used to treat thrombocytopenia in adults with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.

Dosing and Timing

Doptelet (avatrombopag)

For adults with chronic liver disease, Doptelet dosing starts 10 to 13 days prior to the scheduled procedure. The recommended daily dose of Doptelet is based on the patient’s platelet count prior to the scheduled procedure.

• If the platelet count is less than 40 x10⁹/L, the dose is 60mg (3 tablets) orally once a day for 5 days in a row.
• If the platelet count is 40 to less than 50 x10⁹/L, the dose is 40mg (2 tablets) orally once a day for 5 days in a row.
• Patients should undergo their procedure 5 to 8 days after the last dose of Doptelet.

Doptelet is available as a 20 mg oral tablet. It should be taken with food.

Mulpleta (lusutrombopag)

Mulpleta dosing starts 8 to 14 days prior to the scheduled procedure.

• The recommended dosage of Mulpleta is 3 mg taken orally once daily with or without food for 7 days in a row.
• Patients should undergo their procedure 2 to 8 days after the last dose of Mulpleta.

Mulpleta is available as a 3 mg oral tablet in blister packs containing 7 tablets.

Side effects

The most common side effects (≥ 3%) reported with Doptelet are: fever, stomach pain, nausea, headache, fatigue, and swelling in the hands or feet (edema).

The most common side effect (≥ 3%) reported with Mulpleta is headache.

Further information

For further information, see the prescribing information for Doptelet and Mulpleta.