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Humatrope

Generic name: somatropin
Dosage form: injection (6mg, 12 mg, 24 mg)
Drug class: Growth hormones

Medically reviewed by Melisa Puckey, BPharm. Last updated on Apr 1, 2025.

What is Humatrope?

Humatrope (somatropin) is a form of human growth hormone important for the growth of bones and muscles.

Humatrope injection is used to treat growth failure in children and adults who lack natural growth hormones. This includes people with short stature due to Turner syndrome, short stature at birth with no catch-up growth, and other causes.

Humatrope mechanism of action (MOA) is it behaves like a natural human growth hormone by binding to the GH receptor on target cells which signals skeletal growth, muscle growth, and protein synthesis.  Genotropin is a hormone produced in the pituitary gland at the base of the brain. If the pituitary gland doesn’t make enough, or any, human growth hormone it causes a condition called growth-related disorder. 

Humatrope is given as a subcutaneous injection using the Humatrope pen (called the HumatroPen injection device).

Who can use Humatrope?

Humatrope is FDA-approved to treat:

Pediatric Patients with:

Adult Patients for:

Humatrope side effects

Common Humatrope side effects

Common side effects of Humatrope may include:

Serious Humatrope side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Serious breathing problems may occur in patients with Prader-Willi syndrome who use Humatrope. If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.

Other serious side effects may occur, call your doctor at once if you have:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use Humatrope if you have cancer, diabetic retinopathy, or if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems. You should not use this medicine if you have a serious illness due to lung failure or complications from recent surgery, injury, or medical trauma.

Before taking this medicine

You should not use Humatrope if you are allergic to the active ingredient somatropin or any of the inactive ingredients, or if you have:

Tell your doctor if you have ever had:

In some cases, Humatrope should not be used in a child. Certain brands of somatropin contain an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not give this medicine to a child without medical advice.

Tell your doctor if you are pregnant or breastfeeding.

Conditions contraindicated with Humatrope?

How should I use Humatrope?

Humatrope is given as an injection under the skin (subcutaneous injection) using the Humatrope pen device with the Humatrope cartridge.

A healthcare provider can teach you how to properly use the medication by yourself.

Humatrope weekly dose should be divided into equal doses, given either 6 or 7 days per week.

Do not inject into the same place two times in a row.

Prepare your injection only when you are ready to give it. 

For full instructions with diagrams see Humatrope Cartrige Kit Instuctions for Use 

Use only that device that you have been given to administer your medicine.

You may need frequent medical tests.

Follow any diet plan created for you by your doctor or nutrition counselor to help control your condition.

Throw away any Humatrope left over after the expiration date on the label has passed.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Call your doctor if you miss more than 3 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.

What other drugs will affect Humatrope?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Humatrope, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Humatrope interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Humatrope Package Insert 

HCPs and patients often use the Humatrope Package Insert (PI) for more detailed information about this medicine. The Package Insert contains more comprehensive information on Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies, Drug Interaction, and more. Discuss any medical questions you have with your HCP (health care professional). This is not all the information you need to know about this medicine for safe and effective use, and it does not take the place of talking to your doctor about your treatment.

The Package Insert is sometimes called Humatrope Prescribing Information (PI) or FDA label.

Storage 

Ingredients

Active Ingredient: Somatropin

Inactive ingredients: dibasic sodium phosphate, glycine, mannitol.

Company

Humatrope Eli Lilly and Company, Pharmaceutical Delivery Systems, Lilly Corporate Center, Indianapolis, IN 46285, USA

Humatrope Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There are 11 for Humatrope.

Accretropin (somatropin) - Emergent Biosolutions Canada Inc.
Formulation type Strength
Multi-Dose Vial 5 mg/mL Discontinued, Voluntarily Revoked

View Accretropin information in detail.

Genotropin (somatropin) - Pharmacia & Upjohn Company LLC
Formulation type Strength
Multi-Dose Cartridge 12 mg
Multi-Dose Cartridge 5 mg
Pre-Filled Syringe 0.2 mg
Pre-Filled Syringe 0.4 mg
Pre-Filled Syringe 0.6 mg
Pre-Filled Syringe 0.8 mg
Pre-Filled Syringe 1.2 mg
Pre-Filled Syringe 1.4 mg
Pre-Filled Syringe 1.5 mg Discontinued
Pre-Filled Syringe 1.6 mg
Pre-Filled Syringe 1.8 mg
Pre-Filled Syringe 1 mg
Pre-Filled Syringe 2 mg

View Genotropin information in detail.

Humatrope (somatropin) - Eli Lilly and Company
Formulation type Strength
Multi-Dose Cartridge 12 mg
Multi-Dose Cartridge 24 mg
Multi-Dose Cartridge 6 mg
Single-Dose Vial 2 mg Discontinued
Single-Dose Vial 5 mg Discontinued
Norditropin (somatropin) - Novo Nordisk Inc.
Formulation type Strength
Autoinjector 10 mg/1.5 mL
Autoinjector 15 mg/1.5 mL
Autoinjector 30 mg/3 mL
Autoinjector 5 mg/1.5 mL
Multi-Dose Cartridge 10 mg/1.5 mL Discontinued
Multi-Dose Cartridge 15 mg/1.5 mL Discontinued
Multi-Dose Cartridge 5 mg/1.5 mL Discontinued

View Norditropin information in detail.

Nutropin (somatropin) - Genentech, Inc.
Formulation type Strength
Multi-Dose Vial 10 mg Discontinued, Voluntarily Revoked
Multi-Dose Vial 5 mg Discontinued, Voluntarily Revoked

View Nutropin information in detail.

Nutropin AQ (somatropin) - Genentech, Inc.
Formulation type Strength
Autoinjector 10 mg/2 mL
Autoinjector 20 mg/2 mL
Autoinjector 5 mg/2 mL
Multi-Dose Cartridge 10 mg/2 mL Discontinued
Multi-Dose Cartridge 20 mg/2 mL Discontinued
Vial 10 mg/2 mL Discontinued

View Nutropin AQ information in detail.

Omnitrope (somatropin) - Sandoz Inc.
Formulation type Strength
Multi-Dose Cartridge 10 mg/1.5 mL
Multi-Dose Cartridge 5 mg/1.5 mL
Multi-Dose Vial 5.8 mg
Single-Dose Vial 1.5 mg Discontinued

View Omnitrope information in detail.

Saizen (somatropin) - EMD Serono, Inc.
Formulation type Strength
Single-Dose Vial 4 mg Discontinued, Voluntarily Revoked
Single-Dose Vial 5 mg Discontinued, Voluntarily Revoked
Single-Dose Vial 6 mg Discontinued, Voluntarily Revoked
Single-Dose Vial 8.8 mg Discontinued, Voluntarily Revoked

View Saizen information in detail.

Serostim (somatropin) - EMD Serono, Inc.
Formulation type Strength
Multi-Dose Vial 4 mg
Single-Dose Cartridge 6 mg/0.5 mL Discontinued
Single-Dose Vial 5 mg
Single-Dose Vial 6 mg

View Serostim information in detail.

Zomacton (somatropin) - Ferring Pharmaceuticals Inc.
Formulation type Strength
Multi-Dose Vial 10 mg
Multi-Dose Vial 4.8 mg Discontinued
Multi-Dose Vial 5 mg

View Zomacton information in detail.

Zorbtive/Serostim (somatropin) - EMD Serono, Inc.
Formulation type Strength
Multi-Dose Vial 8.8 mg Discontinued

View Zorbtive/Serostim information in detail.

Popular FAQ

How can I tell if a Lilly Humatrope product is fake?

Ways you can tell if a Lilly Humatrope product is fake or authentic include checking features on the packaging, serial numbers, and using digital barcode scanning tools. Avoid buying Humatrope from non-licensed pharmacies or illicit sources. Continue reading

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.