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Drug Interactions between Mounjaro and propofol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

propofol tirzepatide

Applies to: propofol and Mounjaro (tirzepatide)

Medications like tirzepatide can delay the emptying of food and liquid from your stomach. If you are scheduled for a surgery or procedure that requires general anesthesia with propofol, you may have residual contents in your stomach despite following the fasting instructions provided by your doctor. This can increase the risk of regurgitation during anesthesia and having the stomach contents inhaled into the lungs, which can cause inflammation or injury to the lungs, pneumonia, or even death. Therefore, it is important to let your doctor know prior to your surgery or procedure that you are receiving treatment with tirzepatide. Depending on your condition and your individual circumstances, the doctor may instruct you to temporarily withhold treatment with tirzepatide in advance, or they make take extra precaution during anesthesia and your surgery/procedure to minimize the risks. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interfere with the safety of your anesthesia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

propofol food

Applies to: propofol

Alcohol can increase the nervous system side effects of propofol such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with propofol. Do not use more than the recommended dose of propofol, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Moderate

tirzepatide food

Applies to: Mounjaro (tirzepatide)

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer