Modafinil Interactions
There are 519 drugs known to interact with modafinil, along with 5 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 76 are major, 264 are moderate, and 179 are minor.
- View all 519 medications that may interact with modafinil
- View modafinil alcohol/food interactions (4)
- View modafinil disease interactions (5)
Most frequently checked interactions
View interaction reports for modafinil and the medicines listed below.
- Abilify (aripiprazole)
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Klonopin (clonazepam)
- Lamictal (lamotrigine)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Ozempic (semaglutide)
- Prozac (fluoxetine)
- Ritalin (methylphenidate)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Trintellix (vortioxetine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Wellbutrin (bupropion)
- Wellbutrin XL (bupropion)
- Xanax (alprazolam)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Modafinil alcohol/food interactions
There are 4 alcohol/food interactions with modafinil.
Modafinil disease interactions
There are 5 disease interactions with modafinil which include:
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
