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Drug Interactions between magnesium sulfate and streptomycin

This report displays the potential drug interactions for the following 2 drugs:

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Major

streptomycin magnesium sulfate

Applies to: streptomycin and magnesium sulfate

MONITOR CLOSELY: Aminoglycosides possess neuromuscular blocking activity, which may be additive with that of parenteral magnesium, potentially resulting in severe and/or prolonged respiratory depression during concomitant use. Clinical data are limited; however, this interaction has been reported in animal studies. In addition, aminoglycosides may reduce serum magnesium levels.

MANAGEMENT: Close monitoring for increased or prolonged neuromuscular blockade and respiratory depression is recommended during concomitant use, especially in patients with renal impairment and/or with elevated magnesium levels. It may be advisable to avoid administration of aminoglycosides in infants with hypermagnesemia.

References (5)
  1. Watson A, Coffey L, Keogh B, McCann SR (1983) "Severe hypomagnesaemia and hypocalcaemia following gentamicin therapy." Isr J Med Sci, 76, p. 381-3
  2. L'Hommedieu CS, Nicholas D, Armes DA, et al. (1983) "Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin." J Pediatr, 102, p. 629-31
  3. Brunton LL, eds., Lazo JS, Parker KL (2006) "Goodman & Gilman's the Pharmacological Basis of Therapeutics." New York, NY: McGraw-Hill
  4. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  5. Cerner Multum, Inc. "Australian Product Information."

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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