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Drug Interactions between magnesium hydroxide and misoprostol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

miSOPROStol magnesium hydroxide

Applies to: misoprostol and magnesium hydroxide

GENERALLY AVOID: Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid (the active metabolite of misoprostol), although clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.

MANAGEMENT: Use of misoprostol in combination with magnesium-containing antacids is not recommended. If an antacid is needed, one that contains aluminum or calcium should be prescribed.

References (2)
  1. Karim A, Rozek LF, Smith ME, Kowalski KG (1989) "Effects of food and antacid on oral absorption of misoprostol, a synthetic prostaglandin E1 analog." J Clin Pharmacol, 29, p. 439-43
  2. (2001) "Product Information. Arthrotec (diclofenac-misoprostol)." Searle

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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