Drug Interactions between ephedrine and tolazoline
This report displays the potential drug interactions for the following 2 drugs:
- ephedrine
- tolazoline
Interactions between your drugs
ePHEDrine tolazoline
Applies to: ephedrine and tolazoline
MONITOR: Theoretically, the pharmacologic effects of agents that act through agonism at the alpha receptor may be antagonized by those that act via antagonism at the same receptor, and vice versa. Alpha-1 agonists and alpha agonists with beta-agonist effects exert opposing effects on vascular tone and blood pressure than alpha-1 antagonists. Some of these agents act on both alpha-1 and alpha-2 receptors, though they may have a stronger affinity for one or the other. The severity of the interaction may also be influenced by the degree of systemic absorption of each agent.
MANAGEMENT: Monitoring for diminished effects on blood pressure and vasoconstriction is recommended if an alpha-agonist (e.g., epinephrine, norepinephrine, ephedrine, metaraminol) is coadministered with an alpha-antagonist (e.g., phentolamine, phenoxybenzamine, terazosin). If the concomitant alpha agonist being used also acts on beta receptors, the effects of unopposed beta stimulation should also be considered.
References (11)
- (2002) "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals
- (2022) "Product Information. EPHEDrine Sulfate (ePHEDrine)." Akorn Inc
- (2016) "Product Information. Akovaz (ephedrine)." Eclat Pharmaceuticals
- (2016) "Product Information. Adrenaclick Two-Pack (epinephrine)." Amedra Pharmaceuticals LLC
- (2016) "Product Information. Auvi-Q (epinephrine)." sanofi-aventis
- (2016) "Product Information. EpiPen (epinephrine)." Dey Laboratories
- (2016) "Product Information. Adrenalin (epinephrine)." A-S Medication Solutions
- (2016) "Product Information. Epinephrine (epinephrine)." Physicians Total Care
- (2022) "Product Information. Anapen (adrenaline (epinephrine))." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 2.4
- (2023) "Product Information. Epinephrine (EPINEPHrine)." International Medication Systems, Limited
- (2023) "Product Information. Epinephrine (EPINEPHrine)." BPI Labs LLC, SUPPL-10
Drug and food interactions
ePHEDrine food
Applies to: ephedrine
MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.
References (7)
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
- Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
- (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
- (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
- (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
- (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
- (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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