Drug Interactions between Diflucan and Keflex
This report displays the potential drug interactions for the following 2 drugs:
- Diflucan (fluconazole)
- Keflex (cephalexin)
Interactions between your drugs
No interactions were found between Diflucan and Keflex. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Diflucan
A total of 572 drugs are known to interact with Diflucan.
- Diflucan is in the drug class azole antifungals.
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Diflucan is used to treat the following conditions:
- Blastomycosis
- Bone Marrow Transplantation
- Candida Urinary Tract Infection
- Candidemia
- Chronic Mucocutaneous Candidiasis
- Coccidioidomycosis
- Coccidioidomycosis, Meningitis
- Cryptococcal Meningitis, Immunocompetent Host
- Cryptococcal Meningitis, Immunosuppressed Host
- Cryptococcosis
- Esophageal Candidiasis
- Fungal Infection Prophylaxis
- Fungal Infection, Internal and Disseminated
- Fungal Peritonitis
- Fungal Pneumonia
- Histoplasmosis
- Onychomycosis, Fingernail (off-label)
- Oral Thrush
- Sporotrichosis
- Tinea Versicolor (off-label)
- Vaginal Yeast Infection
Keflex
A total of 53 drugs are known to interact with Keflex.
- Keflex is in the drug class first generation cephalosporins.
- Keflex is used to treat the following conditions:
Drug and food interactions
cephalexin food
Applies to: Keflex (cephalexin)
ADJUST DOSING INTERVAL: Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or cephradine. In one pharmacokinetic study (n=12), concurrent administration of zinc sulfate (250 mg, single oral dose) and cephalexin (500 mg, single oral dose) decreased cephalexin maximum concentration (Cmax) and systemic exposure (AUC; 0-inf) by 31.05% and 27.4%, respectively. However, in the same study, when zinc sulfate was administered 3 hours after the cephalexin dose, no significant alteration in cephalexin pharmacokinetics were observed.
MANAGEMENT: Oral medications or mineral supplements that contain zinc are recommended to be administered at least 3 hours after the cephalexin, ceftibuten or cephradine dose.
References (3)
- Ding Y, Jia Y, Li F, et al. (2011) "The Effect of Staggered Administration of Zinc Sulfate on the Pharmacokinetics of Oral Cephalexin*" Br J Clin Pharmacol, 73, p. 422-7
- World Health Organization (2020) WHO Public Assessment Reports (WHOPARs) https://extranet.who.int/pqweb/medicines/prequalification-reports/whopars
- Okamura M, Terada t, KatsuraT, Saito H, Inui K (2003) "Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2" Pharm Res, 20, p. 1389-93
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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