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Drug Interactions between clindamycin / niacinamide / spironolactone / tretinoin topical and isotretinoin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tretinoin topical ISOtretinoin

Applies to: clindamycin / niacinamide / spironolactone / tretinoin topical and isotretinoin

GENERALLY AVOID: Concomitant use of isotretinoin with topical exfoliative or keratolytic anti-acne agents may increase local skin irritation.

MANAGEMENT: Concurrent use should generally be avoided.

References (2)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Pharmaceutical Society of Australia (2006) APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp

Drug and food interactions

Moderate

ISOtretinoin food

Applies to: isotretinoin

GENERALLY AVOID: The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction. The mechanism has not been established.

MANAGEMENT: Alcohol consumption should be avoided during isotretinoin therapy.

References (1)
  1. (2001) "Product Information. Accutane (isotretinoin)." Roche Laboratories

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Retinoic acid derivatives

Therapeutic duplication

The recommended maximum number of medicines in the 'retinoic acid derivatives' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'retinoic acid derivatives' category:

  • clindamycin/niacinamide/spironolactone/tretinoin topical
  • isotretinoin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer