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Drug Interactions between ceftriaxone and heparin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

cefTRIAXone heparin

Applies to: ceftriaxone and heparin

Ceftriaxone has been associated with an increase in prothrombin time and episodes of bleeding. These effects may potentiate the effects of heparin. Usually, no special management is necessary, but the patient should be monitored for bleeding if ceftriaxone and heparin must be given together. Vitamin K has been successfully used to treat cephalosporin-induced coagulopathies.

References (2)
  1. Angaran DM, Dias VC, Arom KV, et al. (1987) "The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient." Ann Surg, 206, p. 155-61
  2. Haubenstock A, Schmidt P, Zazgornik J, et al. (1983) "Hypoprothrombinaemic bleeding associated with ceftriaxone." Lancet, 1, p. 1215-6

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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