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Drug Interactions between carvedilol and Diflucan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

fluconazole carvedilol

Applies to: Diflucan (fluconazole) and carvedilol

MONITOR: Coadministration with moderate inhibitors of CYP450 2C9 may increase the serum levels and effects of carvedilol. The mechanism is inhibition of CYP450 2C9, one of the primary isoenzymes involved in the metabolism of carvedilol. According to the prescribing information, CYP450 2C9 is thought to be of importance in the O-methylation pathway of S(-)-carvedilol. Further reductions in heart rate or cardiac conduction may occur.

MANAGEMENT: Patients should be monitored for signs of increased carvedilol effects, such as bradycardia or heart block.

References (2)
  1. (2001) "Product Information. Coreg (carvedilol)." SmithKline Beecham
  2. (2023) "Product Information. Coreg (carvedilol)." Waylis Therapuetics LLC

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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