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Drug Interactions between anastrozole and DHEA

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

anastrozole dehydroepiandrosterone (prasterone)

Applies to: anastrozole and DHEA (dehydroepiandrosterone)

GENERALLY AVOID: Theoretically, estrogen-containing drugs may negate the pharmacologic effects of aromatase inhibitors in the treatment of hormone-dependent breast cancer. Aromatase inhibitors induce a state of estrogen deprivation in postmenopausal women by inhibiting the conversion of androgens to estrogens in adrenal and ovarian tissues, thus estrogen administration would be expected to reverse their therapeutic effects.

MANAGEMENT: Use of estrogen-containing products should be avoided during aromatase inhibitor therapy.

References (3)
  1. (2001) "Product Information. Femara (letrozole)." Novartis Pharmaceuticals
  2. (2001) "Product Information. Arimidex (anastrozole)." Astra-Zeneca Pharmaceuticals
  3. (2001) "Product Information. Aromasin (exemestane)." Pharmacia and Upjohn

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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