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Drug Interactions between acyclovir and varicella virus vaccine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

acyclovir varicella virus vaccine

Applies to: acyclovir and varicella virus vaccine

GENERALLY AVOID: Concomitant use of live, attenuated varicella virus vaccine or zoster vaccine with acyclovir, famciclovir, or valacyclovir may result in diminished immunologic response to the vaccine. Although clinical data are lacking, theoretical concern exists that antiviral activity against the vaccine strain may prevent a sufficient degree of replication to occur in order to induce a protective immune response. Acyclovir, specifically, has demonstrated activity against the Oka strain of live, attenuated varicella-zoster virus used in the vaccines.

MANAGEMENT: Acyclovir, famciclovir, and valacyclovir should not be used for at least 24 hours before administration of live, attenuated varicella virus vaccine or zoster vaccine. In addition, these antiviral agents should generally be avoided for 14 days after vaccination.

References (2)
  1. (2017) "Product Information. Zovirax (acyclovir)." Mylan Pharmaceuticals Inc
  2. US Centers for Disease Control and Prevention (CDC) (2017) Recommended immunization schedule for adults aged 19 years or older, United States, 2017 https://www.cdc.gov/vaccines/schedules/downloads/adult/adult-combined-schedule-bw.pdf

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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